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Guangyi Wang, Robert Tam, Devron Averett: Purine L-nucleosides, analogs and uses thereof. ICN Pharmaceuticals, Robert D Fish, Rutan & Tucker, November 12, 2002: US06479463 (73 worldwide citation)

Novel purine L-nucleoside compounds are disclosed, in which both the purine rings and the sugar are either modified, functionalized or both. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to tre ...


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Kandasamy Ramasamy, Robert Tam, Devron Averett: Monocyclic L-Nucleosides, analogs and uses thereof. ICN Pharmaceuticals, Robert D Fish, Fish & Associates, October 10, 2000: US06130326 (68 worldwide citation)

Novel monocyclic L-Nucleoside compounds have the general formula ##STR1## Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. Viewed in terms of mechanism, embodiments of the novel ...


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Guangyi Wang, Robert Tam, Devron Averett: Purine L-nucleosides, analogs and uses thereof. ICN Pharmaceuticals, Robert D Fish, Sandra Thompson, Fish & Associates, January 21, 2003: US06509320 (45 worldwide citation)

Novel purine L-nucleoside compounds are disclosed, in which both the purine rings and the sugar are either modified, functionalized or both. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to tre ...


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Robert Tam, Devron Averett, Guangyi Wang, Kanda Ramasamy: L-8-oxo-7-propyl-7,8-dihydro-(9H)-guanosine. Robert D Fish, Fish & Associates, September 24, 2002: US06455690 (35 worldwide citation)

Novel nucleosides having the structure of Formula 1 and Formula 2 are contemplated. In one aspect of the invention, controlled release dosage forms are particularly contemplated. Further, alternative routes of administration of the nucleosides having the structure of Formula 1 or Formula 2 are conte ...


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Robert Tam, Guangyi Wang, Devron Averett, Kandasamy Ramasamy: Cytokine related treatments of disease. Ribapharm, Robert D Fish, Rutan & Tucker, July 23, 2002: US06423695 (10 worldwide citation)

Nucleosides and other compounds to selectively modulate Th1 and Th2 responses relative to each other in the treatment of disease. In one aspect of the invention, administration of a nucleoside or other compound reduces the dosage at which a primary drug is administered. In another aspect of the inve ...


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Kandasamy Ramasamy, Rajanikanth Bandaru, Devron Averett: Method of producing tiazofurin and other c-nucleosides. Icn Pharmaceuticals, yang liqin, July 26, 2000: CN98806383

C-nucleosides are synthesized by a method in which a sugar is derivatized in a single step to provide a heterocycle at the C1 position, and then the heterocycle is aromatized in another single step. In one class of preferred embodiments a cyano sugar is converted into thiocarboxamide, and subsequent ...