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Rajeshwar Singh, Nian E Zhou, Deqi Guo, Ronald G Micetich: 3,4-Disubstituted azetidin-2-one derivatives useful as cysteine proteinase regulators. Synphar Laboratories, Nikaido Marmelstein Murray & Oram, September 28, 1999: US05959123 (26 worldwide citation)

The present invention is based on the discovery that certain 3,4-disubstituted-azetidin-2-one derivatives exhibit excellent cysteine proteinase inhibitory activity which can be used for treatment of different diseases such as muscular dystrophy, myocardial infarction, bone resorption, arthritis, can ...


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Robert Edward Babine, Shu Hui Chen, Ivan Collado, Cristina Garcia Paredes, John Irvin Glass, Deqi Guo, Ling Jin, Jason Eric Lamar, Raymond Samuel Parker III, Nancy June Snyder, Xicheng David Sun, Mark Joseph Tebbe, Frantz Victor, Q May Wang, Yvonne Yee Mai Yip, Robert B Perni, Luc Farmer: Peptidomimetic protease inhibitors. Vertex Pharmaceuticals Incorporated, Honigman Miller Schwartz and Cohn, Jonathan P O Brien, Kathryn D Soulier, October 26, 2010: US07820671 (17 worldwide citation)

The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The in ...


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Robert Edward Babine, Shu Hui Chen, Jason Eric Lamar, Nancy June Snyder, Xicheng Sun, Mark Joseph Tebbe, Frantz Victor, Q May Wang, Yvonne Yee Mai Yip, Ivan Collado, Cristina Garcia Paredes, Raymond Samuel Parker III, Ling Jin, Deqi Guo, John Irvin Glass: Peptidomimetic protease inhibitors. Vertex Pharmaceuticals Incorporated, Honigman Miller Schwartz and Cohn, Jonathan P O Brien, Kathryn D Soulier, August 28, 2012: US08252923 (10 worldwide citation)

The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The in ...


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Wei Yuan Zhang, Alan L Maycock, Michael Anthony Marella, Virendra Kumar, Forrest Gaul, An Chih Chang, Deqi Guo: Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritis therewith. Adolor Corporation, Imre Balogh, April 25, 2000: US06054445 (8 worldwide citation)

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compound of formulae IIA, having the structure: ##STR1## wherein R.sub.1, R.sub.2 ;


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Rajeshwar Singh, Nian E Zhou, Deqi Guo, Jadwiga Kaleta, Ronald George Micetich: 3-Substituted-4-oxa-1-azabicyclo �3,2,0!heptan-7-one as cysteine protease inhibitors. Synphar Laboraties, Nikaido Marlelstein Murray & Oram, July 20, 1999: US05925633 (4 worldwide citation)

The use of certain 3-substituted-4-oxa-1-azabicyclo�3,2,0! heptan-7-one derivatives of general formula I, ##STR1## or physiologically acceptable salts thereof or isomers thereof, as active ingredients for the preparation of pharmaceutical composition and treatment of different diseases associated wi ...