1
Raymond F Schinazi, Dennis C Liotta, Chung K Chu, J Jeffrey McAtee, Junxing Shi, Yongseok Choi, Kyeong Lee, Joon H Hong: 2′-Fluoronucleosides. Emory University, University of Georgia Research Foundation, Sherry M Knowles Esq, Josephine Young, King & Spalding, February 19, 2002: US06348587 (115 worldwide citation)

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae:


2
Dennis C Liotta, Raymond F Schinazi, Woo Baeg Choi: Method for the synthesis, compositions and use of 2-deoxy-5-fluoro-3-thiacytidine and related compounds. Emory University, Kilpatrick & Cody, May 11, 1993: US05210085 (83 worldwide citation)

The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevent ...


3
Dennis C Liotta, Woo Baeg Choi: Method and compositions for the synthesis of BCH-189 and related compounds. Emory University, Kilpatrick & Cody, April 20, 1993: US05204466 (74 worldwide citation)

The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, .beta.-B ...


4
Raymond F Schinazi, Dennis C Liotta, Chung K Chu, J Jeffrey McAtee, Junxing Shi, Yongseok Choi, Kyeong Lee, Joon H Hong: 2′-fluoronucleosides. Emory University, Sherry M Knowles Esq, King & Spalding, June 28, 2005: US06911424 (72 worldwide citation)

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is ...


5
Dennis C Liotta, Woo Baeg Choi: Method and compositions for the synthesis of BCH-189 and related compounds. Emory University, Cheryl K Kilpatrick & Cody Zalesky, July 23, 1996: US05539116 (62 worldwide citation)

The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, .beta.-B ...


6
Raymond F Schinazi, Dennis C Liotta: Compositions containing 5-fluoro-2,3-didehydro-2,3-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent. Emory University, Kilpatrick Stockton, December 30, 1997: US05703058 (59 worldwide citation)

A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a �5-carboxamido or 5-fluoro!-2',3'-dideoxy-2',3'-didehydro-pyrimidine nucleoside or a �5-carboxamido or 5-fluoro!-3'-modified ...


7
Raymond F Schinazi, Dennis C Liotta: �5--Caboxamido or 5--fluoro!--�2, 3--unsaturated or 3--modified!--pyrimidine nucleosides. Emory University, Sherry M Knowles, Jacqueline King & Spalding Haley, May 18, 1999: US05905070 (53 worldwide citation)

A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a �5-carboxamido or 5-fluoro!-2',3'-dideoxy-2',3'-didehydro-pyrimidine nucleoside or a �5-carboxamido or 5-fluoro!-3'-modified ...


8
Dennis C Liotta, Raymond F Schinazi, Woo Baeg Choi: Method for the synthesis, compositions and use of 2-deoxy-5-fluoro-3-thiacytidine and related compounds. Emory University, Sherry M Knowles, Jacqueline King & Spalding Haley, September 29, 1998: US05814639 (52 worldwide citation)

The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevent ...


9
Raymond F Schinazi, Dennis C Liotta, Chung K Chu, J Jeffrey McAtee, Junxing Shi, Yongseok Choi, Kyeong Lee, Joon H Hong: 2′-Fluoronucleosides. Emory University, The University of Georgia Research Foundation, King & Spalding, December 11, 2007: US07307065 (50 worldwide citation)

A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is ...


10
Raymond F Schinazi, Dennis C Liotta: Treatment of HIV by administration of &bgr;-D-2′, 3′-didehydro-2′,3′-dideoxy-5-fluorocytidine (D4FC). Emory University, Sherry M Knowles Esq, King & Spalding, May 15, 2001: US06232300 (49 worldwide citation)

A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or 5-fluoro]-2′,3′-dideoxy-2′,3′-didehydro-pyrimidine nucleoside or a [5-carboxamido or 5-fluo ...