11
Andrew Wu, Benjamin J Clark, Erik Thai, Nicolas Zadno, Denise Zarins: Methods and systems for thermally-induced renal neuromodulation. Medtronic Ardian Luxembourg r l, May 24, 2016: US09345900 (3 worldwide citation)

Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or pe ...


12
Sowmya Ballakur, Robert J Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S Leung: Devices, systems and methods for evaluation and feedback of neuromodulation treatment. Medtronic Ardian Luxembourg r l, May 24, 2016: US09345530 (3 worldwide citation)

The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during ...


13
Michael A Evans, Denise Zarins, Dino De Cicco, Kelvin Ning, Alexander Khairkhahan, Tyler Jon Strang: Apparatus and methods for clot dissolution. Covidien, Thomas M Johnston Esq, March 24, 2015: US08986241 (3 worldwide citation)

Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic age ...


14
Mark E Deem, Hanson Gifford III, Denise Zarins, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R Levin: Methods and apparatus for renal neuromodulation. Medtronic Ardian Luxembourg r l, March 22, 2016: US09289255 (2 worldwide citation)

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the ...


15
Denise Zarins, Hanson Gifford III, Mark Deem, Douglas Sutton, Howard R Levin, Mark Gelfand: Methods and apparatus for bilateral renal neuromodulation. Medtronic Ardian Luxembourg r l, November 8, 2016: US09486270 (2 worldwide citation)

Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or el ...


16
Mark E Deem, Hanson Gifford III, Denise Zarins, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R Levin: Methods and apparatus for renal neuromodulation. Medtronic Ardian Luxembourg r l, January 13, 2015: US08934978 (2 worldwide citation)

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the ...


17
Denise Zarins, Hanson Gifford III, Mark Deem, Douglas Sutton, Howard R Levin, Mark Gelfand: Methods for therapeutic renal neuromodulation. Medtronic Ardian Luxembourg r l, May 2, 2017: US09636174 (2 worldwide citation)

Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusio ...


18
Denise Zarins, Hanson Gifford III, Mark Deem, Douglas Sutton, Howard R Levin, Mark Gelfand: Methods for bilateral renal neuromodulation. Medtronic Ardian Luxembourg r l, February 23, 2016: US09265558 (2 worldwide citation)

Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or el ...


19
Denise Zarins: Methods and apparatus for multi-vessel renal neuromodulation. Medtronic Ardian Luxembourg r l, August 18, 2015: US09108040 (2 worldwide citation)

Methods and apparatus are provided for multi-vessel neuromodulation, e.g., via a pulsed electric field. Such multi-vessel neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation ...


20
Naomi Buckley, Benjamin J Clark, Michael Cummins, Danny Donovan, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Seamus Ledwith, Gwenda McMullin, Karun D Naga, Stephen Nash, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Mark Gelfand, Mark S Leung, Barry Mullins: Neuromodulation cryotherapeutic devices and associated systems and methods. Medtronic Ardian Luxembourg r l, June 23, 2015: US09060754 (2 worldwide citation)

Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment includes an elongated shaft and a cooling assembly at a distal portion of the shaft. The shaft can be configured to locate t ...