51
Denise Demarais, Benjamin J Clark, Nicolas Zadno, Erik Thai, Hanson Gifford: Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach. Ardian, Perkins Coie, Patent Sea, August 30, 2007: US20070203549-A1

Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other c ...


52
Denise Demarais, Nicolas Zadno: Methods and apparatus for inducing controlled renal neuromodulation. Ardian, Perkins Coie, Patent Sea, March 22, 2007: US20070066957-A1

Methods and apparatus are provided for inducing, monitoring and controlling renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. In some embodiments, tissue impedance, conductance or conductivity may be monitored to determine the effects of pulsed elect ...


53
Michael A Evans, Denise Demarais, Alexander Khairkhahan, Dino Decicco: Apparatus and method for removing occlusive material within blood vessels. Bacchus Vascular, Townsend And Townsend And Crew, January 8, 2004: US20040006306-A1

An apparatus for treating an occlusive region of a blood vessel includes a catheter including a first lumen extending from an end port to a first side port, and a second lumen extending from a proximal end of the catheter to a second side port. A balloon is mounted on the catheter between the first ...


54
Mark Deem, Hanson Gifford, Denise Demarais, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R Levin: Apparatuses for renal neuromodulation. Ardian, Perkins Coie, Patent Sea, November 15, 2007: US20070265687-A1

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the ...


55
David W Snow, Denise Demarais, Stuart Lin: Devices and methods for controlling expandable prostheses during deployment. XTENT, Townsend And Townsend And Crew, September 25, 2008: US20080234795-A1

A catheter for delivering a prosthesis to a treatment site in a body lumen comprises an elongate flexible member and a sheath slidably disposed thereover. A plurality of self-expanding tubular prostheses are carried in axially spaced apart locations along the elongate member, within the sheath. The ...


56
Michael A Evans, Denise Demarais, Dino De Cicco, Kelvin Ning, Alexander Khairkhahan, Tyler Jon Strang: Apparatus and methods for clot dissolution. Bacchus Vascular, Townsend And Townsend And Crew, December 12, 2002: US20020188276-A1

Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic age ...


57
Denise Demarais, Michael A Evans, Stephen A Leeflang, Christian S Eversull: Systems and methods for clot disruption and retrieval. Bacchus Vascular, Townsend And Townsend And Crew, October 17, 2002: US20020151906-A1

Thrombectomy and other treatments are achieved using a catheter having a positioning cage and a macerator within the positioning cage. The catheter is introduced to a target body lumen, typically a blood vessel, and a positioning cage deployed at a treatment site. The macerator is then operated to d ...


58
Mark Deem, Hanson S Gifford, Denise Demarais: Systems and methods for selective denervation of heart dysrhythmias. Luce Forward Hamilton & Scripps, November 24, 2005: US20050261672-A1

Methods and apparatus are provided for selective denervation of conduction pathways in the heart for the treatment of dysrhythmias, including one or more ablation or electroporation catheters having electrodes for stimulating, targeting, and ablating fat pad tissue and other cardiac tissue to select ...


59
Denise Demarais, Nicolas Zadno, Benjamin J Clark, Erik Thai, Howard R Levin, Mark Gelfand: Methods and apparatus for thermally-induced renal neuromodulation. Ardina, Perkins Coie, Patent Sea, December 6, 2007: US20070282407-A1

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or ...


60
Michael A Evans, Denise Demarais, Dino De Cicco, Kelvin Ning, Alexander Khairkhahan, Tyler Jon Strang, Jody Maria Cimbalo, Stephen Leeflang: Apparatus and methods for clot dissolution. Bacchus Vascular, Townsend And Townsend And Crew, July 24, 2003: US20030139751-A1

Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, agitate the clot and agent, and aspirate broken-up clot from the blood vessel. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a cl ...