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Rao Kalla, Thao Perry, Elfaith Elzein, Vaibhav Varkhedkar, Xiaofen Li, Prabha Ibrahim, Venkata Palle, Dengming Xiao, Jeff Zablocki: A2B adenosine receptor antagonists. CV Therapeutics, Brian Lewis, Pauline Ann Clarke, J Elin Hartrum, December 20, 2005: US06977300 (34 worldwide citation)

Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, cardiovascular diseases, neurological disorders, and diseases related to undesirable angio ...


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Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Birong Zhang, Christine Chabot, Steven Do: Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Covenentech, Viksnins Harris & Padys PLLP, November 22, 2011: US08063050 (25 worldwide citation)

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatmen ...


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Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Jun Li, Christine Chabot: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Genertech, Viksnins Harris & Padys PLLP, August 23, 2011: US08003651 (22 worldwide citation)

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...


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Rao Kalla, Thao Perry, Elfatih Elzein, Vaibhav Varkhedkar, Xiaofen Li, Prabha Ibrahim, Venkata Palle, Dengming Xiao, Jeff Zablocki: adenosine receptor antagonists, A. CV Therapeutics, Brian Lewis, J Elin Hartrum, CV Therapeutics, December 4, 2007: US07304070 (12 worldwide citation)

Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, cardiovascular diseases, neurological disorders, and diseases related to undesirable angio ...


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Rao Kalla, Thao Perry, Elfatih Elzein, Vaibhav Varkhedkar, Xiaofen Li, Prabha Ibrahim, Venkata Palle, Dengming Xiao, Jeff Zablocki: adenosine receptor antagonists, A. CV Therapeutics, J Elin Hartrum, CV Therapeutics, January 8, 2008: US07317017 (9 worldwide citation)

Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, cardiovascular diseases, neurological disorders, and diseases related to undesirable angiog ...


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Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Birong Zhang, Christine Chabot, Steven Do: Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array Biopharma, Genentech, Viksnins Harris & Padys PLLP, October 7, 2014: US08853199 (7 worldwide citation)

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatmen ...


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Ian S Mitchell, James F Blake, Rui Xu, Nicholas C Kallan, Dengming Xiao, Keith Lee Spencer, Josef R Bencsik, Eli M Wallace, Stephen T Schlachter, Anna L Banka, Jun Liang, Brian Safina, Jun Li, Christine Chabot: Pyrimidyl cyclopentanes as AKT protein kinase inhibitors. Array BioPharma, Genentech, Viksnins Harris & Padys PLLP, September 30, 2014: US08846681 (7 worldwide citation)

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for ...


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Rao Kalla, Thao Perry, Elfatih Elzein, Vaibhav Varkhedkar, Xiaofen Li, Prabha Ibrahim, Venkata Palle, Dengming Xiao, Jeff Zablocki: A2B adenosine receptor antagonists. Gilead Palo Alto, J Elin Hartrum, June 22, 2010: US07741331 (7 worldwide citation)

Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, cardiovascular diseases, neurological disorders, and diseases related to undesirable angio ...


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Xumu Zhang, Dengming Xiao: Chiral ligands, transition-metal complexes thereof and uses thereof in asymmetric reactions. The Penn State Research Foundation, Ohlandt Greeley Ruggiero & Perle L, February 25, 2003: US06525210 (7 worldwide citation)

Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include phospholanes, P,N ligands, N,N ligands, biphenols, and chelating phosphines. The ferrocene-based irridium (R,R)-f-binaphane complex reduces imines to th ...



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