1
Demetrios P Papahadjopoulos, Francis C Szoka Jr: Method of encapsulating biologically active materials in lipid vesicles. Kane Dalsimer Kane Sullivan and Kurucz, November 25, 1980: US04235871 (766 worldwide citation)

The disclosure is of a method for encapsulating biologically active materials in synthetic, oligolamellar lipid vesicles (liposomes). The method comprises providing a mixture of lipid in organic solvent and an aqueous mixture of the material for encapsulation, emulsifying the provided mixture, remov ...


2
Francis C Szoka Jr, Demetrios P Papahadjopoulos: Method of inserting DNA into living cells. Kane Dalsimer Kane Sullivan & Kurucz, July 19, 1983: US04394448 (226 worldwide citation)

A method of inserting deoxyribonucleic acid or fragments thereof into a living cell, which comprises; encapsulating the DNA or fragment in a lipid vesicle and bringing the vesicle in contact with said cell, whereby insertion occurs.


3
Demetrios P Papahadjopoulos, Francis C Szoka Jr: Method of encapsulating biologically active materials in lipid vesicles. Kane Dalsimer Kane Sullivan and Kurucz, December 23, 1980: US04241046 (170 worldwide citation)

The disclosure is of a method for encapsulating biologically active materials in synthetic, oligolamellar lipid vesicles (liposomes). The method comprises providing a mixture of lipid in organic solvent and an aqueous mixture of the material for encapsulation, emulsifying the provided mixture, remov ...


4
Frank J Martin, Demetrios P Papahadjopoulos, Wayne L Hubbell: Thiol reactive liposomes. The Regents of the University of California, Majestic Gallagher Parsons & Siebert, January 31, 1984: US04429008 (71 worldwide citation)

Liposomes are provided which have a plurality of thiol reactive groups extending outward of the liposomal bilayer. The liposomes form stable covalent bonds with ligands having thiol groups, such as Fab' fragments. Particularly preferred liposomes include maleimide moieties as the thiol reactive grou ...


5
Demetrios P Papahadjopoulos, Timothy D Heath: Liposome conjugates and diagnostic methods therewith. The Regents of the University of California, Majestic Gallagher Parsons & Siebert, July 1, 1986: US04598051 (60 worldwide citation)

A number of naturally occurring antibodies to human erythrocyte surface antigens are capable of combining with their specific antigens (for example, Rhesus factor), but are not capable of producing visible hemagglutination. Also, the sensitivity of many diagnostic methods, such as in human blood typ ...


6
Christopher C Benz, Demetrios P Papahadjopoulos, John W Park, Keelung Hong, Dmitri Kirpotin: Immunoliposomes that optimize internalization into target cells. The Regents of the University of California, Townsend and Townsend and Crew, April 10, 2001: US06214388 (37 worldwide citation)

The present invention provides for immunoliposomes that optimizes internalization of a drug into target cells bearing a characteristic cell surface marker. The immunoliposomes comprise an Fab′ domain of an antibody that specifically binds the characteristic marker, an amphipathic vesicle-forming lip ...


7
Francis C Szoka Jr, Demetrios P Papahadjopoulos: Plant nutriment compositions and method of their application. Kane Dalsimer Kane Sullivan & Kurucz, July 19, 1983: US04394149 (34 worldwide citation)

The disclosure is of the use of plant nutriments encapsulated in synthetic lipid vesicles to nourish plants. SP


8
Demetrios P Papahadjopoulos, Timothy D Heath: Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes. The Regents of the University of California, Majestic Parsons Siebert & Hsue, February 21, 1989: US04806466 (7 worldwide citation)

A number of naturally occurring antibodies to human erythrocyte surface antigens are capable of combining with their specific antigens (for example, Rhesus factor), but are not capable of producing visible hemagglutination. Also, the sensitivity of many diagnostic methods, such as in human blood typ ...


9
Christopher C Benz, Demetrios P Papahadjopoulos, John W Park, Keelung Hong, Dmitri Kirpotin: Immunoliposomes that optimize internationalization into target cells. The Regents of the University of California, Townsend and Townsend and Crew, March 24, 2009: US07507407 (4 worldwide citation)

The present invention provides for immunoliposomes that optimizes internalization of a drug into target cells bearing a characteristic cell surface marker. The immunoliposomes comprise an Fab′ domain of an antibody that specifically binds the characteristic marker, an amphipathic vesicle-forming lip ...


10
Christopher C Benz, Demetrios P Papahadjopoulos, Francis C Szoka legal representative, John W Park, Keelung Hong, Dmitri Kirpotin: Immunoliposomes that optimize internationalization into target cells. The Regents of the University of California, Townsend and Townsend and Crew, January 18, 2011: US07871620 (2 worldwide citation)

The present invention provides for immunoliposomes that optimizes internalization of a drug into target cells bearing a characteristic cell surface marker. The immunoliposomes comprise an Fab′ domain of an antibody that specifically binds the characteristic marker, an amphipathic vesicle-forming lip ...