1
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin: Very large scale immobilized polymer synthesis using mechanically directed flow paths. Affymax Technologies, Kevin R Kaster, Vern Norviel, January 24, 1995: US05384261 (374 worldwide citation)

A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are flowed through the channels, the substrate is rotated by a rotatin ...


2
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymax Technologies, Townsend and Townsend and Crew, October 14, 1997: US05677195 (239 worldwide citation)

A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rota ...


3
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymetrix, Banner & Witcoff, March 21, 2000: US06040193 (168 worldwide citation)

An array is created by moving a dispenser toward a solid support until a tip of the dispenser touches the support, withdrawing the tip from the surface and releasing a drop of 5 nanoliters or less in an area smaller than 1 mm.sup.2 to create an array of at least 100 spots.


4
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial kit for polymer synthesis. Affymetrix, Banner & Witcoff, October 24, 2000: US06136269 (72 worldwide citation)

A device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage ...


5
Vladimir Drbal, Calvin Chow, Rick Smethers, Debra A Ross, Gregory Kirk, Briggs Jonathan, Lev Leytes, Suresh N Mehta: Analytical slide with porous filter membrane. October 12, 1993: US05252293 (46 worldwide citation)

This invention encompasses a slide reading assembly, and a slide with a porous filter membrane wherein the slide has a means for aligning the slide within a filter assembly to filter reagents on predetermined portions of the porous filter membrane and also to position the slide in a slide reading as ...


6
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymetrix, Banner & Witcoff, February 1, 2005: US06849462 (37 worldwide citation)

A method for producing arrays by depositing a resist on a substrate, selectively removing a portion of the resist to expose localized areas, dispensing a monomer to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly or indirectly to the su ...


7
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin: Very large scale immobilized polymer synthesis using mechanically directed flow paths. Affymetrix, Townsend & Townsend & Crew, March 23, 1999: US05885837 (34 worldwide citation)

A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are flowed through the channels, the substrate is rotated by a rotatin ...


8
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymetrix, Banner & Witcoff, September 13, 2005: US06943034 (31 worldwide citation)

A method for producing arrays by spacing a dispenser a distance from a surface of a support, dispensing a volume containing a compound in a single coupling step of less than 5 nl to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the compound to bind directly or in ...


9
George Pontis, Michael Lacy, Vladimir Drbal, Calvin Chow, Thomas Smith, Rick Smethers, Debra A Ross, Gregory Kirk, Jonathan Briggs, Lev Leytes, Suresh N Mehta: Analytical work station. Molecular Devices Corporation, Banner & Allegretti, June 25, 1996: US05529752 (13 worldwide citation)

This invention encompasses a work station for conducting assays which comprises filtering assembly, a slide reading assembly, and a slide with a porous filter membrane wherein the slide has a means for aligning the slide within the filter assembly to filter reagents on predetermined portions of the ...


10
James L Winkler, Stephen P A Fodor, Christopher J Buchko, Debra A Ross, Lois Aldwin, Douglas N Modlin: Combinatorial strategies for polymer synthesis. Affymetrix, Banner & Witcoff, March 8, 2005: US06864101 (11 worldwide citation)

A method for producing polymer arrays by spacing a dispenser a distance from a surface of a support, dispensing a volume containing a monomer in a single coupling step of less than 5 nl to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly ...



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