1
Debouck Christine Marie, Rosenberg Martin: Immunodiagnostic assays using chimeric antigens.. Smithkline Beckman, November 30, 1988: EP0293184-A2 (4 worldwide citation)

An immunodiagnostic device comprising an antibody bound to a solid support and chimeric antigen having a first and second antigenic region the first antigenic region being reactive with the bound antibody but not being cross reactive with antibodies recognising said second antigenic region. In parti ...


2
Abdel Meguid Sherin Salaheldin, Qiu Xiayang, Whitlock Smith Ward Jr, Janson Cheryl Ann, Hoog Susan S, Culp Jeffrey, Debouck Christine Marie: Herpesviral proteases, compositions capable of binding them and uses thereof.. Smithkline Beecham, November 19, 1997: EP0807687-A2 (2 worldwide citation)

Novel herpes viral protease crystalline structures are identified which have an active site formed by the three amino acids Ser, His and His. Also disclosed are methods of identifying inhibitors of these proteases and/or active sites.


3
Debouck Christine Marie, Ho Yen Sen, Rosenberg Martin: Proteolytic deficient e. coli.. Smithkline Beckman, April 1, 1987: EP0216747-A2 (2 worldwide citation)

This invention relates to a method of stably expressing a foreign polypeptide coding sequence which is not stably expressed by a htpR host due to degradation by proteases under the control of the htpR gene which comprises transforming a htpR mutant host with a plasmid containing the foreign polypept ...


4
Debouck Christine Marie, Brake David Alan: Inhibition of disease associated with immunodeficiency virus infection. Smithkline Beecham Corporation, Debouck Christine Marie, Brake David Alan, KINZIG Charles M, October 17, 1991: WO/1991/015224 (1 worldwide citation)

Pharmaceutical compositions comprising agents which inhibit $i(tat) protein RGD-mediated cell adhesion are useful in inhibiting progression of disease states associated with infection in an animal Immunodeficiency Virus.


5
Mooney Jeffrey L, Debouck Christine Marie: Methods for identifying genes essential to the growth of an organism. Smithkline Beecham, October 13, 1999: EP0948646-A1

The present invention provides methods for identifying genes essential to the growth of an organism using a grid prepared from a genomic library of a selected organism. Genes identified as essential by this method and proteins encoded thereby are also provided. In addition, methods of using these ge ...


6
Dilella Anthony G, Debouck Christine Marie: Hsv-2 ul26 gene, capsid proteins, immunoassays and protease inhibitors. Smithkline Beecham, June 5, 1996: EP0714399-A1

Essentially pure HSV-2 UL26 gene products and fragments thereof including mature HSV-2 protease and active fragments thereof are disclosed. Essentially pure HSV-2 UL26.5 gene products and fragments thereof including mature HSV-2 capsid protein and functional fragments are disclosed. Isolated nucleic ...


7
Debouck Christine Marie, Brake David Alan Rittenhouse L: Inhibition of disease associated with immunodeficiency virus infection.. Smithkline Beecham, January 13, 1993: EP0522081-A1

Pharmaceutical compositions comprising agents which inhibit tat protein RGD-mediated cell adhesion are useful in inhibiting progression of disease states associated with infection in an animal Immunodeficiency Virus.


8
Mooney Jeffrey L, Debouck Christine Marie: Method for rapid gap closure. Smithkline Beecham Corporation, Mooney Jeffrey L, Debouck Christine Marie, GIMMI Edward R, June 18, 1998: WO/1998/026096

Methods for gap closure and contiguous sequence assembly of an organism using high density grids from a series of random genomic libraries prepared from isolated DNA of the selected organism are provided.


9
Debouck Christine Marie: Use of hiv protease cleavage site to express mature proteins. Smithkline Beecham Corporation, LENTZ Edward T, June 14, 1990: WO/1990/006369

The invention discloses methods for producing mature protein products. A host cell which has been co-transformed with two recombinant DNA molecules, the first of said recombinant DNA molecules comprises a fusion protein nucleotide sequence, wherein the fusion protein encoded by said coding sequence ...


10
Dilella Anthony G, Debouck Christine Marie: Hsv-2 ul26 gene, capsid proteins, immunoassays and protease inhibitors. Smithkline Beecham Corporation, Dilella Anthony G, Debouck Christine Marie, JERVIS Herbert H, March 2, 1995: WO/1995/006055

Essentially pure HSV-2 UL26 gene products and fragments thereof including mature HSV-2 protease and active fragments thereof are disclosed. Essentially pure HSV-2 UL26.5 gene products and fragments thereof including mature HSV-2 capsid protein and functional fragments are disclosed. Isolated nucleic ...