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Deborah A Eppstein, Philip L Felgner, Thomas R Gadek, Gordon H Jones, Richard B Roman: N[.omega.,(.omega.-1)-dialkyloxy]- and N-[.omega.,(.omega.-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor. Syntex, David A Lowin, Tom M Moran, January 30, 1990: US04897355 (361 worldwide citation)

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, ...


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Jonathan A Eppstein, Deborah A Eppstein, Joseph Kost, Robert S Langer: Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers. Non Invasive Monitoring Company, Thorpe North & Western, October 17, 1995: US05458140 (356 worldwide citation)

A method of enhancing the permeability of the skin or mucosa to an analyte for diagnostic purposed is described utilizing ultrasound or ultrasound plus a chemical enhancer. If desired the ultrasound may be modulated by means of frequency modulation, amplitude modulation, phase modulation and/or comb ...


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Jonathan A Eppstein, Deborah A Eppstein: Enhancement of transdermal delivery with ultrasound and chemical enhancers. Non Invasive Monitoring Company, Thorpe North & Western, August 29, 1995: US05445611 (289 worldwide citation)

A method of enhancing the permeability of the skin or mucosa to a biologically active permeant or drug is described utilizing ultrasound or ultrasound plus a chemical enhancer. If desired the ultrasound may be modulated by means of frequency modulation, amplitude modulation, phase modulation and/or ...


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Deborah A Eppstein, Brian B Schryver: Controlled release of macromolecular polypeptides. Syntex, Lester E Johnson, Tom M Moran, Alan M Krubiner, October 9, 1990: US04962091 (195 worldwide citation)

An active agent delivery system for the controlled administration of macromolecular polypeptides which comprises a micro-suspension of water-soluble components in a polylactide matrix.


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Deborah A Eppstein, Philip L Felgner, Thomas R Gadek, Gordon H Jones, Richard B Roman: N-(.omega.,(.omega.-1)-dialkyloxy)- and N-(.omega.,(.omega.-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor. Syntex, David A Lowin, Tom M Moran, August 7, 1990: US04946787 (160 worldwide citation)

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, ...


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Deborah A Eppstein, Philip L Felgner, Thomas R Gadek, Gordon H Jones, Richard B Roman: N-(.omega., (.omega.-1)-dialkyloxy)- and N-(.omega., (.omega.-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor. Syntex, David A Lowin, Tom M Moran, May 4, 1993: US05208036 (131 worldwide citation)

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, ...


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Deborah A Eppstein, Philip L Felgner, Thomas R Gadek, Gordon H Jones, Richard B Roman: N-.omega.,(.omega.-1)-dialkyloxy)- and N-(.omega.,(.omega.-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor. Syntex, David A Lowin, Tom M Moran, September 17, 1991: US05049386 (105 worldwide citation)

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, ...


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Deborah A Eppstein, Philip L Felgner, Thomas R Gadek, Gordon H Jones, Richard B Roman: N-[1, (1-1)-dialkyloxy]-and N-[1, (1-1)-dialkenyloxy]-alk-1-yl-n,n,n-tetrasubstituted ammonium lipids and uses therefor. Syntex, Heller Ehrman White & McAuliffe, August 13, 1996: US05545412 (73 worldwide citation)

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, ...


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Deborah A Eppstein, Elizabeth Fraser Smith, Thomas R Matthews: Method for enhancing the anti-infective activity of muramyldipeptide derivatives. Syntex, Grant D Green, Tom M Moran, Alan M Krubiner, August 4, 1987: US04684625 (38 worldwide citation)

Co-administration of a muramyldipeptide derivative with liposomes enhances the anti-infective activity of the muramyldipeptide derivative.