1
Leitao Eugenia Ribeiro de Sous, de Bruijn Joost Dick, Wen Hai Bo, de Groot Klaas: Device for incorporation and release of biologically active agents. Matrix Medical, November 12, 1997: EP0806212-A1 (41 worldwide citation)

The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process ...


2
Layrolle Pierre Jean Francois, de Groot Klaas, de Bruijn Joost Dick, Van Blitterswijk Clemens Anton: Method for coating medical implants. Isotis, March 22, 2000: EP0987031-A1 (17 worldwide citation)

The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. ...


3
De Groot Klaas, Jansen Johannes Arnoldus: A percutaneous implant.. Stichting Biomat Scienc Cent, May 9, 1990: EP0367354-A1 (13 worldwide citation)

A percutaneous implant comprises a subcutaneous part (1) and a percutaneous part (10), the former comprising a part consisting of a fibre mesh sheet. The fibre mesh sheet preferably is made of sintered metallic fibre, the metal preferably comprising titanium or the titanium alloy Ti6Al4V. The porosi ...


4
De Groot Klaas: A method of preparing an implant material, and two-component kit suitable therefor.. Stichting Biomaterials Science, October 1, 1986: EP0196143-A2 (12 worldwide citation)

The invention relates to a method of preparing an implant material in which particles of a bioactive ceramic biomaterial, such as apatite, of a size of at least 200 mu m are mixed with water and a water-soluble hydrocolloid. The invention also relates to a two-component kit for preparing the implant ...


5
De Groot Klaas: A process for preparing an implant material which releases medicines in the body.. Stichting Biomaterials Science, October 23, 1985: EP0159087-A1 (9 worldwide citation)

Implant material for the release of medicine in bone tissues or soft tissues, comprising a medicine and a carrier composed of calcium sulphate and calcium carbonate.


6
De Groot Klaas, Roukema Pieter Andries, Van Nieuw Amerongen Arie: Composition for protecting teeth against decalcification.. Stichting Biomaterials Science, March 19, 1986: EP0174704-A2 (9 worldwide citation)

This invention relates to a composition for protecting teeth against decalcification, in particular against acid-action-induced decalcification. For this purpose the composition according to the invention, which, for example, may be a toothpaste, or an artificial saliva, contains human mucins or syn ...


7
Yuan Huipin, de Bruijn Joost Dick, de Groot Klaas: Method of improving the osteoinductivity of bioactive materials. Progentix B V I O, November 2, 2006: EP1716873-A1 (8 worldwide citation)

The invention relates to methods of improving the osteoinductivity of bioactive materials, to bioactive materials having improved osteoinductivity as well as bone (re)generation scaffolds produced therefrom and to the use of such materials and scaffolds in methods of treatment.


8
De Groot Klaas: A process for preparing an implant material which releases medicines in the body.. Stichting Biomaterials Science, October 23, 1985: EP0159089-A1 (7 worldwide citation)

Implant material for the release of medicine in bone tissues or soft tissues, comprising a medicine and a carrier therefor, composed of calcium sulphate and calcium monohydrogen phosphate.


9
Layrolle Pierre Jean Francois, de Groot Klaas, de Bruijn Joost Dick, Van Blitterswijk Clemens A: Method for coating medical implant. Isotis, April 4, 2000: JP2000-093503 (4 worldwide citation)

PROBLEM TO BE SOLVED: To easily coat the surface of a medical implant with a bioactive carbonated calcium phosphate layer by dipping and preparing a transplantable device in a highly concentrated calcified solution at a low temperature.SOLUTION: In order to coat a medical implant with a bioactive ca ...


10
De Bruijn Joost Dick, de Groot Klaas, Huipin Yuan, Van Blitterswijk Clemens Anton: Ceramic material for osteoinduction comprising micropores in the surface of macropores. Isotis, March 22, 2000: EP0987032-A1 (2 worldwide citation)

The invention relates to an osteoinductive biomaterial, which is based on a ceramic material and which has a total porosity of 20 to 90%, wherein macropores are present having a size ranging from 0.1 to 1.5 mm, and wherein micropores are present having a size ranging from 0.05 to 20 mu m. The invent ...