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Leitao Eugenia Ribeiro de Sous, de Bruijn Joost Dick, Wen Hai Bo, de Groot Klaas: Device for incorporation and release of biologically active agents. Matrix Medical, November 12, 1997: EP0806212-A1 (41 worldwide citation)

The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process ...


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De Bruijn Joost Dick, Van Apeldoorn Aart Alexander, Peters Wilhelmina Hendrika Lam: Tissue engineering. Isotis, January 2, 2002: EP1167517-A1 (23 worldwide citation)

The invention relates to a specific process for producing tissue in vitro. The present approach to tissue engineering allows for an optimal control of the culturing process, leading to proliferation or differentiation as desired, and its conditions. Particularly, the invention facilitates the mainte ...


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Layrolle Pierre Jean Francois, de Groot Klaas, de Bruijn Joost Dick, Van Blitterswijk Clemens Anton: Method for coating medical implants. Isotis, March 22, 2000: EP0987031-A1 (17 worldwide citation)

The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. ...


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Goedemoed Jacob Hillebrand, Hennink Wilhelmus Everhardus, Bezemer Jeroen Mattijs, Feijen Jan, Van Blitterswijk Clemens Anton, de Bruijn Joost Dick: Polyetheresters copolymers as drug delivery matrices. Osteotech, March 25, 1998: EP0830859-A2 (17 worldwide citation)

A composition for delivering a biologically active agent to a host. The composition comprises a product including a biologically active agent encapsulated in a matrix comprising a copolymer, of a polyalkylene glycol and an aromatic polyester, such as a polyethylene glycol terephthalate/polybutylene ...


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De Bruijn Joost Dick, Bovell Yvonne Pearl, Van Den Brink Jennigje, Van Blitterswijk Clemens Anton: Device for tissue engineering bone comprising biodegradable thermoplastic copolyester and cultured cells. Isotis, January 20, 1999: EP0891783-A1 (16 worldwide citation)

A device for bone tissue engineering is described which comprises a scaffold material consisting of a bioactive, osteoconductive and bone-bonding segmented thermoplastic copolyester and cultured osteogenic or osteoprogenitor cells, especially bone cells. The copolyester consists essentially of a mul ...


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Yuan Huipin, de Bruijn Joost Dick, de Groot Klaas: Method of improving the osteoinductivity of bioactive materials. Progentix B V I O, November 2, 2006: EP1716873-A1 (8 worldwide citation)

The invention relates to methods of improving the osteoinductivity of bioactive materials, to bioactive materials having improved osteoinductivity as well as bone (re)generation scaffolds produced therefrom and to the use of such materials and scaffolds in methods of treatment.


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Van Blitterswijk Clemens Anton, de Bruijn Joost Dick, Bovell Yvonne Pearl: Method for in vitro production of bone. Matrix Medical, October 1, 1997: EP0798374-A1 (7 worldwide citation)

The invention relates to a method for in vitro production of bone tissue, comprising the steps of: (a) applying undifferentiated mammalian cells, in particular autologous marrow cells, on a substrate: (b) directly contacting said cells with a culture medium for a sufficient time to produce a continu ...


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De Bruijn Joost Dick, Yuan Huipin: Osteoinductive calcium phosphate. Progentix B V I O, September 5, 2007: EP1829564-A1 (5 worldwide citation)

The invention relates to an osteoinductive biomaterial based on calcium phosphate, wherein the material is in the form of microparticles having a particle size ranging from about 50 to about 1500 [mu]m, and wherein the porosity of the material consists essentially of micropores in a size range of 0. ...


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Layrolle Pierre Jean Francois, de Groot Klaas, de Bruijn Joost Dick, Van Blitterswijk Clemens A: Method for coating medical implant. Isotis, April 4, 2000: JP2000-093503 (4 worldwide citation)

PROBLEM TO BE SOLVED: To easily coat the surface of a medical implant with a bioactive carbonated calcium phosphate layer by dipping and preparing a transplantable device in a highly concentrated calcified solution at a low temperature.SOLUTION: In order to coat a medical implant with a bioactive ca ...