1
Stuart Edwards, John Gaiser, David Utley, Scott West, Jay Chin: Integrated tissue heating and cooling apparatus. Curon Medical, Ryan Kromholz & Manion S C, August 14, 2001: US06273886 (489 worldwide citation)

Systems and methods integrate the control of an energy generator, to supply energy to an electrode structure to heat a tissue region, and the control of a pumping mechanism, to supply cooling fluid to control tissue temperature in the region.


2
Stuart Edwards, John Gaiser, David Utley, Scott West, Jay Chin: Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions. Curon Medical, Ryan Kromholz & Manion SC, July 10, 2001: US06258087 (465 worldwide citation)

Expandable assemblies for treating a tissue region at or near a sphincter comprises a support basket formed from an array of spines. A mechanism flexes the spines to expand and collapse the basket. Electrodes carried by the spines for advancement in a path to penetrate the tissue region upon expansi ...


3
David Utley, Scott West, John Gaiser, Rachel Croft: Systems and methods for treating dysfunctions in the intestines and rectum. Curon Medical, Ryan Kromholz & Manion S C, November 11, 2003: US06645201 (286 worldwide citation)

A sphincter tissue region is treated using a support structure sized for advancement into the anal canal. At least one electrode is carried by the structure. A mechanism is coupled to the electrode to move the electrode between a first position retracted in the support structure and a second positio ...


4
Stuart Edwards, John Gaiser, David Utley, Scott West, Jay Chin: Graphical user interface for association with an electrode structure deployed in contact with a tissue region. Curon Medical, Ryan Kromholz & Manion S C, March 19, 2002: US06358245 (269 worldwide citation)

Systems and methods deploy an electrode structure in contact with the tissue region. The electrode structure carries a sensor at a known location on the electrode structure to monitor an operating condition. The systems and methods provide an interface, which generate an idealized image of the elect ...


5
Stuart Edwards, John Gaiser, David Utley, Scott West, Jay Chin, Ronald Lax: Vacuum-assisted systems and methods for treating sphincters and adjoining tissue regions. Curon Medical, Ryan Kromholz & Manion S C, December 4, 2001: US06325798 (268 worldwide citation)

Systems and methods treat a tissue region at or near a sphincter by deploying a carrier, which carries an electrode that can be advanced to penetrate tissue. Negative pressure is applied through a suction port on the carrier near the electrode, to draw tissue in the tissue region inward against the ...


6
David Utley, Scott West, John Gaiser, Rachel Croft: Mederi Therapeutics, Ryan Kromholz & Manion S C, April 20, 2010: US07699844 (201 worldwide citation)

A sphincter tissue region is treated using a support structure sized for advancement into the anal canal. At least one electrode is carried by the structure. A mechanism is coupled to the electrode to move the electrode between a first position retracted in the support structure and a second positio ...


7
John Gaiser, David Utley: Systems and methods for treating tissue in the crura. Curon Medical, Ryan Kromholz & Manion SC, April 15, 2003: US06547776 (153 worldwide citation)

Tissue in the crura is treated by advancing a tissue penetrating element from a catheter tube through a wall of the esophagus. The tissue penetrating element is operated to affect a tightening of the crura, e.g., to treat hiatal hernia.


8
David Utley, Stuart D Edwards, Richard L Goode: Systems and methods for ablating discrete motor nerve regions. VidaDerm, Ryan Kromholz & Manion S C, October 31, 2000: US06139545 (127 worldwide citation)

Systems and method ablate motor nerve tissue by inserting an operative element connectable to an ablation energy generator into a defined percutaneous tissue region. The systems and methods apply stimulant energy in the defined percutaneous tissue region to stimulate targeted motor nerve tissue prio ...


9
Stuart Edwards, John Gaiser, David Utley, Scott West, Jay Chin: Actively cooled electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions. Curon Medical, Ryan Kromholz & Manion S C, August 27, 2002: US06440128 (107 worldwide citation)

An assembly for treating tissue at or near the sphincter includes a support structure for deployment in a tissue region, and a an electrode carried by the support structure. The support structure includes a spine with a lumen having an exit port, the electrode being deployable from the exit port. Th ...


10
Stuart D Edwards, David Utley, Ronald G Lax, Theodore R Kucklick, Peter H Muller: Sphincter treatment apparatus. Mederi Therapeutics, Ryan Kromholz & Manion S C, January 19, 2010: US07648500 (39 worldwide citation)

A sphincter treatment apparatus includes an energy delivery device introduction member including a proximal end with a first radius of curvature and a distal end with a second radius of curvature. The introduction member is configured to be introduced into the sphincter in a non-deployed state and t ...