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Rino Antonio Bit, Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Ian Reginald Kilford, Neil Derek Miller, Tiziana Scoccitti: Phenyl compounds. Glaxo Group, R Steve Thomas, November 4, 2008: US07446222 (2 worldwide citation)

Compounds of formula (I) or derivatives thereof: wherein A, B, Z, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.


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Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Ian Reginald Kilford, Xiao Qing Lewell, Alan Naylor, Riccardo Novelli: (2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives. Glaxo Group, J Scott Young, June 19, 2007: US07232821 (1 worldwide citation)

Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2, Rx, R8, R9 and n are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.


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Daisy Joe Du Bois, David Garrett Loughhead, Hans Maag, Jason Manka, David Bernard Smith, David Nigel Hurst: Cyclopropyl aryl amide derivatives and uses thereof. Roche Palo Alto, Robert C Hall, May 25, 2010: US07723391

Compounds of the formula: wherein Ar1, Ar2, R1 and R2 are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.


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Michael John Broadhurst, Christopher Huw Hill, David Nigel Hurst, Philip Stephen Jones, Paul Brittain Kay, Ian Reginald Kilford, Robert Murray McKinnell: Oxamide IMPDH inhibitors. Hoffmann La Roche, George W Johnston, Dennis P Tramaloni, March 15, 2005: US06867299

Disclosed are compounds of the general formula which are oxamide derivatives and inhibitors of the enzyme inosine monophosphate dehydrogenase (IMPDH).


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Emmanuel Hubert Demont, Jag Paul Heer, John Skidmore, Ian David Wall, Jason Witherington, Thomas Daniel Heightman, David Nigel Hurst, Christopher Norbert Johnson: Oxadiazole derivatives active on sphingosine-1-phosphate (S1P). Glaxo Group, Linda E Hall, John L Lemanowicz, July 17, 2012: US08222245

The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.


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Rino Antonio Bit, Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Ian Reginald Kilford, Neil Derek Miller, Tiziana Scoccitti: Phenyl compounds. Glaxosmithkline, Corporate Intellectual Property Mai B475, October 19, 2006: US20060235057-A1

Compounds of formula (I) or derivatives thereof: wherein A, B, Z, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.