1
Joseph P Vacanti, Anthony Atala, David J Mooney, Robert S Langer: Massachusetts Institute of Technology, Arnall Golden & Gregory, February 10, 1998: US05716404 (218 worldwide citation)

Methods and compositions are described herein for reconstruction or augmentation of breast tissue. Dissociated cells, preferably muscle cells, are implanted in combination with a suitable biodegradable, polymeric matrix to form new tissue. There are two forms of matrices which can be used: a polymer ...


2
William L Murphy, Martin C Peters, David J Mooney, David H Kohn: Mineralization and biological modification of biomaterial surfaces. The Regents of the University of Michigan, Williams Morgan and Amerson, July 27, 2004: US06767928 (89 worldwide citation)

Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various method ...


3
David J Mooney, Robert B Rutherford: Engineering oral tissues. The Regents of the University of Michigan, Arnold White & Durkee, March 23, 1999: US05885829 (83 worldwide citation)

Disclosed are methods for regenerating dental and oral tissues from viable cells using ex vivo culture on a structural matrix. The regenerated oral tissues and tissue-matrix preparations thus provided have both clinical applications in dentistry and oral medicine and are also useful in in vitro toxi ...


4
William L Murphy, David J Mooney, David H Kohn, Gabriel C Spalding, Matthew T Dearing: Mineral and cellular patterning on biomaterial surfaces. The Regents of the University of Michigan, Williams Morgan and Amerson, April 1, 2003: US06541022 (53 worldwide citation)

Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various method ...


5
David J Mooney, Kamal H Bouhadir, Wai Kung Wong, Jon A Rowley: Polymers containing polysaccharides such as alginates or modified alginates. The Regents of the University of Michigan, Millen White Zelano & Branigan P C, November 4, 2003: US06642363 (52 worldwide citation)

Materials which contain polysaccharide chains, particularly alginate or modified alginate chains. The polysaccharide chains may be included as side chains or auxiliary chains from a backbone polymer chain, which may also be a polysaccharide. Further, the polysaccharide chains may be cross-linked bet ...


6
David J Mooney, Robert S Langer, Joseph P Vacanti: Localized delivery of factors enhancing survival of transplanted cells. Children&apos s Medical Center, Massachusetts Institute of Technology, Clark & Elbing, August 28, 2001: US06281015 (49 worldwide citation)

Growth factors and/or angiogenic factors are administered in combination with dissociated cells to be transplanted, preferably in microspheres with the cells on or in a polymeric matrix, to enhance survival and proliferation of the transplanted cells. Examples demonstrate that epidermal growth facto ...


7
Leatrese Harris, David J Mooney, Lonnie Shea: Open pore biodegradable matrices. The Regents of the University of Michigan, Millen White Zelano & Branigan, August 28, 2001: US06281256 (45 worldwide citation)

The invention is directed to a process for preparing porous polymer materials by a combination of gas forming and particulate leaching steps. The invention is also directed to porous polymer material prepared by the process, particularly having a characteristic interconnected pore structure, and to ...


8
Lawrence J Bonassar, Jon A Rowley, David J Mooney: Injection molding of living tissues. University of Massachusetts, Fish & Richardson P C, August 10, 2004: US06773713 (43 worldwide citation)

The invention features methods of making living tissue constructs having a predetermined shape by providing a negative mold having a defined shape; suspending isolated tissue precursor cells in a hydrogel to form a liquid hydrogel-precursor cell composition; introducing the liquid hydrogel-precursor ...


9
Jeffrey D Drost, David J Mooney, Jon R Salvati: Inspection system and method. Everest VIT, Synnestvedt & Lechner, March 25, 2003: US06538732 (38 worldwide citation)

A system comprises: (a) an imaging system having an imaging device for transmitting an electrical signal corresponding to an area being imaged, and magnification functionality adapted to magnify the imaged area; (b) a portable support system for supporting the imaging system having a power supply fo ...


10
Algert J Maldanis, Robert I Courts, Dennis Dutkevitch, David J Mooney: Cold drink vending mechanism. C Power Companies, John W Montgomery, August 9, 1994: US05335818 (23 worldwide citation)

A vending mechanism for a cylindrical article dispenser of a type having a column of stacked cylindrical articles moved along a dispensing pathway by a force, such as by the force of gravity, is disclosed, which has an escapement mechanism which is attachable in operative alignment with a vending pa ...