1
David J Kyle: Arachidonic acid and methods for the production and use thereof. Martek Corporation, Baker & Botts L, August 19, 1997: US05658767 (166 worldwide citation)

The present invention relates to processes for the production of arachidonic acid containing oils, which preferably are substantially free of eicosapentaneoic acid. The invention also relates to compositions containing such oils, in an unmodified form, and to uses of such oils. In a preferred embodi ...


2
David J Kyle, Sue E Reeb, Valerie J Sicotte: Pharmaceutical composition and dietary supplement containing docosarexaenoic acid obtained from dinoflagellates. Martek Biosciences Corporation, Banner & Allegretti, February 20, 1996: US05492938 (142 worldwide citation)

A pharmaceutical composition and a dietary supplement comprising a single cell oil containing at least 20% docosahexaenoic acid (DHA) in triglyceride form are presented. The single cell oil is extracted from biomass produced by cultivating heterotrophic microalgae of the class Dinophyceae in an aero ...


3
David J Kyle: Microbial oil mixtures and uses thereof. Martek Corporation, Banner Birch McKie & Beckett, December 20, 1994: US05374657 (138 worldwide citation)

The present invention relates to compositions including blends of microbial oils, methods of using such compositions, particularly as supplements for infant formula, and methods of increasing the amount of long chain polyunsaturated fatty acids in infant formula.


4
David J Kyle, Sue E Reeb, Valerie J Sicotte: Production of docosahexaenoic acid by dinoflagellates. Martek Corporation, Banner Birch McKie & Beckett, April 18, 1995: US05407957 (107 worldwide citation)

This invention relates to a process for producing a single cell edible oil containing DHA, to the oil itself and to uses for the oil. Marine microorganisms are cultivated in fermentors and induced to produce the single cell oil which subsequently is recovered by extraction with solvents.


5
David J Kyle, Sue E Reeb, Valerie J Sicotte: Infant formula and baby food containing docosahexaenoic acid obtained from dinoflagellates. Martek Biosciences Corporation, Banner Birch McKie & Beckett, March 14, 1995: US05397591 (69 worldwide citation)

Infant formula and baby food compositions are presented which contain single cell edible oil which is recovered from dinoflagellates and which lacks unpleasant tastes and fishy odors. This single cell edible oil comprises at least 70% triglycerides which contain about 20-35% docosahexaenoic acid (DH ...


6
David J Kyle: Microbial oil mixtures and uses thereof. Martek Corporation, August 27, 1996: US05550156 (68 worldwide citation)

The present invention relates to compositions including blends of microbial oils, methods of using such compositions, particularly as supplements for infant formula, and methods of increasing the amount of long chain polyunsaturated fatty acids in infant formula.


7
David J Kyle, Raymond Gladue: Eicosapentaenoic acids and methods for their production. Martek Corporation, Rothwell Figg Ernst & Kurz, September 14, 1993: US05244921 (49 worldwide citation)

This invention describes a process for producing single cell edible oils containing eicosapentaenoic acid (EPA) from heterotrophic diatoms. The diatoms are cultivated in a fermentor in a nutrient solution containing nitrogen and silicate. Withdrawal of the nitrogen followed by withdrawal of the sili ...


8
F C Thomas Allnutt, David J Kyle, Arthur R Grossman, Kirk R Apt: Methods and tools for transformation of eukaryotic algae. Carnegie Institution of Washington, Martek Biosciences Corporation, Baker & Botts L, February 22, 2000: US06027900 (47 worldwide citation)

Genetic fusions for use in genetic engineering of eukaryotic algae employ a promoter from a light harvesting protein fused to a protein of interest. The fusions can be introduced and selected using an antibiotic resistance determinant. One gene useful for such selection is the sh ble gene encoding a ...


9
Kirk Emil Apt, F C Thomas Allnutt, David J Kyle, James Casey Lippmeier: Trophic conversion of obligate phototrophic algae through metabolic engineering. Martek Biosciences Corporation, Sterne Kessler Goldstein & Fox P L L C, May 10, 2011: US07939710 (41 worldwide citation)

Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of gen ...


10
David J Kyle, Raymond Gladue: Eicosapentaenoic acid-containing oil and methods for its production. Martek Biosciences Corporation, Banner & Allegretti, October 22, 1996: US05567732 (20 worldwide citation)

This invention describes a process for producing single cell edible oils containing eicosapentaenoic acid (EPA) from heterotrophic diatoms. The diatoms are cultivated in a fermentor in a nutrient solution containing nitrogen and silicate. Depletion of the nitrogen followed by depletion of the silica ...