1
Howard P Ng, Zhihong Li, Danny P C McGee, Oliver L Saunders, Guoxian Wu, David J King, Valeri Martichonok, Sharon Boyd, Thomas J Lobl: Disulfide prodrugs and linkers and stabilizers useful therefor. Medarex, Darby & Darby PC, January 24, 2006: US06989452 (44 worldwide citation)

The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moi ...


2
Warren J Blatz, David J King, Gordon G Wilson: Multi-tiered system of leveller units. Tri Lynx Corporation, Dykema Gossett, October 17, 1995: US05458315 (30 worldwide citation)

A multi-tiered system of leveller units for the levelling of recreational vehicles. The leveller units each comprise a planar body, with upper and lower surfaces circumscribed by edges. The body of each unit bears a plurality of pins upwardly extending from spaced locations in the upper surface and ...


3
David G Gorenstein, David J King, Daniel A Ventura, Allan R Brasier: Combinatorial selection of oligonucleotide aptamers. Board of Regents the University of Texas System, Sanford E Warren Jr, Edwin S Flores, Gardere Wynne Sewell, July 23, 2002: US06423493 (30 worldwide citation)

A random combinatorial selection method is disclosed for the construction of oligonucleotide aptamers in which nuclease resistance is conferred by the inclusion of modified nucleotides. The modified nucleotides are incorporated during PCR amplification to form achiral modified oligonucleotides. Thio ...


4
Howard P Ng, Zhi Hong Li, Danny P C McGee, Oliver L Saunders, Guoxian Wu, David J King, Valeri Martichonok, Sharon Elaine Boyd, Thomas J Lobl: Disulfide prodrugs and linkers and stabilizers useful therefor. Medarex, Darby & Darby PC, March 3, 2009: US07498302 (21 worldwide citation)

The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moi ...


5
Warren J Blatz, David J King, Gordon G Wilson: Multi-tiered system of leveller units. Tri Lynx Corporation, Dykema Gossett, July 12, 1994: US05328154 (10 worldwide citation)

A multi-tiered system of leveller units for the levelling of recreational vehicles. The leveller units each comprise a planar body, with upper and lower surfaces circumscribed by edges. The body of each unit bears a plurality of pins upwardly extending from spaced locations in the upper surface and ...


6
Robbie J Jorgenson, David J King: Current-injecting/tunneling light-emitting device and method. Lightwave Photonics, David J King, Charles A Lemaire, Lemaire Patent Law Firm P L L C, November 30, 2010: US07842939 (7 worldwide citation)

An apparatus and method for making it. Some embodiments include a light-emitting device having a light-emitting active region; a tunneling-barrier (TB) structure facing adjacent the active region; a TB grown-epitaxial-metal-mirror (TB-GEMM) structure facing adjacent the TB structure, wherein the TB- ...


7
Alison J Witte, Denise Williams, Josephine M Cardarelli, David J King, David B Passmore: Interferon alpha antibodies and their uses. Medarex, Baker Botts L, September 27, 2011: US08025882 (3 worldwide citation)

The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological a ...


8
Josephine M Cardarelli, Tseng Hui Timothy Chen, David J King, Christopher R Bebbington, Sarah Lee Pogue, Francis J Carr, Stephen Williams: Humanized antibodies to interferon alpha receptor-1 (IFNAR-1). Medarex, Baker Botts L, November 17, 2009: US07619070 (3 worldwide citation)

Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.


9
David G Gorenstein, David J King, Daniel A Ventura, Allan R Brasier: Combinatorial selection of oligonucleotide aptamers. Board of Regents The University of Texas System, Chalker Flores, Edwin S Flores, Daniel J Chalker, February 20, 2007: US07179894 (1 worldwide citation)

A random combinatorial selection method is disclosed for the construction of oligonucleotide aptamers in which nuclease resistance is conferred by the inclusion of modified nucleotides. The modified nucleotides are incorporated during PCR amplification to form achiral modified oligonucleotides. Thio ...


10
David J King: Method and system for blockchain variant using digital signatures. MASTERCARD INTERNATIONAL INCORPORATED, Buchanan Ingersoll & Rooney PC, April 17, 2018: US09948467 (1 worldwide citation)

A method for using digital signatures for signing blockchain transactions includes: generating a domain key pair comprising a domain private key and a domain public key, wherein the domain public key is signed after generation; receiving a plurality of member public keys, wherein each member public ...