1
Glenn Albrecht, Sydney Brenner, Robert B DuBridge, David H Lloyd, Michael C Pallas: Massively parallel signature sequencing by ligation of encoded adaptors. Lynx Therapeutics, Stephen C Macevicz, January 11, 2000: US06013445 (197 worldwide citation)

The invention provides a method of nucleic acid sequence analysis based on the ligation of one or more sets of encoded adaptors to the terminus of a target polynucleotide. Encoded adaptors whose protruding strands form perfectly matched duplexes with the complementary protruding strands of the targe ...


2
Sergei M Gryaznov, David H Lloyd: Oligonucleotide clamps having diagnostic applications. Lynx Therapeutics, Cooley Godward Castro Huddleson & Tatum, December 5, 1995: US05473060 (56 worldwide citation)

Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a target polynucleotide and one or more pairs of b ...


3
Sergei M Gryaznov, David H Lloyd: Oligonucleotide clamps. Lynx Therapeutics, Stephen C Macevicz, Vincent M Powers, April 21, 1998: US05741643 (15 worldwide citation)

Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a target polynucleotide and one or more pairs of b ...


4
Sergei M Gryaznov, David H Lloyd: Oligonucleotide clamps having diagnostic and therapeutic applications. Lynx Therapeutics, Stephen C Macevicz, Vincent M Powers, October 6, 1998: US05817795 (12 worldwide citation)

Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a target polynucleotide and one or more pairs of b ...


5
Sergei M Gryaznov, David H Lloyd: Oligonucleotide clamps having diagnostic and therapeutic applications. Lynx Therapeutics, Stephen C Macevicz, Vincent M Powers, April 11, 2000: US06048974 (7 worldwide citation)

Compounds referred to herein as oligonucleotide clamps are provided that stably bind to target polynucleotides in a sequence-specific manner. The oligonucleotide clamps comprise one or more oligonucleotide moieties capable of specifically binding to a target polynucleotide and one or more pairs of b ...


6
David H Lloyd, Robert J DeFranco, Charles S Ladd: Biopolymer synthesis apparatus and method. Applied Biosystems, Peter J Dehlinger, Vincent M Powers, October 31, 1995: US05462748 (7 worldwide citation)

A cartridge containing a dry polymer composition carrying trapped biopolymer subunits for use in synthesis of biopolymer chains provides a discrete unit for stepwise supply of subunits, such as protected amino acids, in an automated apparatus for biopolymer synthesis. The composition is swellable in ...


7
David H Lloyd, Robert J DeFranco: Subunit delivery composition and method. Applied Biosystems, Peter J Dehlinger, Joseph H Smith, March 29, 1994: US05298259 (4 worldwide citation)

A polymer composition having a biopolymer subunit entrapped in a swellable polymer matrix is described. The composition may be supplied in a disposable cartridge, for use in delivering a solution of the subunit in an automated biopolymer synthesis operation.


8
David H Lloyd: Body with deployable support means. British Aerospace Public Company, Cushman Darby & Cushman, February 5, 1991: US04989812 (2 worldwide citation)

Automatically deployable support means for a body requiring, in use, to stand in an upright position on a surface, for example a land surface or the sea bed has a plurality of legs pivoted to the body so as to be movable from a stowed position to a support position in which they extend generally out ...


9
Glenn Albrecht, Sydney Brenner, Robert B DuBridge, David H Lloyd, Michael C Pallas: Massively parallel signature sequencing by ligation of encoded adaptors. Illumina, Reinhart Boerner Van Deuren s c, January 10, 2012: USRE043097

The invention provides a method of nucleic acid sequence analysis based on the ligation of one or more sets of encoded adaptors to the terminus of a target polynucleotide. Encoded adaptors whose protruding strands form perfectly matched duplexes with the complementary protruding strands of the targe ...


10
Jen i Mao, Shujun Luo, Alan Ewing, David H Lloyd, Stephen C MacEvicz: Sequencing by proxy. Perkins Coie, November 24, 2005: US20050260570-A1

The invention provides methods, kits and materials for determinining simultaneously signature sequences of a population of tagged polynucleotides. Size ladders of polynucleotide fragments are generated from the population of tagged polynucleotides that contain a plurality of size classes. After the ...