1
John McCafferty, Anthony Richard Pope, Kevin Stuart Johnson, Henricus Renerus Jacobus Mattheus Hoogenboom, Andrew David Griffiths, Ronald Henry Jackson, Kaspar Philipp Holliger, James David Marks, Timothy Piers Clackson, David John Chiswell, Gregory Paul Winter, Timothy Peter Bonnert: Methods for producing members of specific binding pairs. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, October 19, 1999: US05969108 (520 worldwide citation)

A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containi ...


2
Kevin Stuart Johnson, Gregory Paul Winter, Andrew David Griffiths, Andrew John Hammond Smith, Peter Michael Waterhouse: Methods for producing members of specific binding pairs. Cambridge Antibody Technology, Medical Research Council, Marshall O Toole Gerstein Murray & Borun, March 31, 1998: US05733743 (509 worldwide citation)

Methods, recombinant host cells and kits are disclosed for the production of members of specific binding pairs (sbp), e.g. antibodies, using display on the surface of secreted replicable genetic display packages (rgdps), e.g. filamentous phage. To produce a library of great diversity, recombination ...


3
Andrew David Griffiths, Hendricus Renerus Jacobus Mattheus Hoogenboom, James David Marks, John McCafferty, Gregory Paul Winter, Geoffrey Walter Grigg: Production of anti-self antibodies from antibody segment repertoires and displayed on phage. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, March 23, 1999: US05885793 (297 worldwide citation)

Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self-antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous ...


4
Kaspar Philipp Holliger, Andrew David Griffiths, Hendricus Renerus Jacobus Matheus Hoogenboom, Magnus Malmqvist, James David Marks, Brian Timothy McGuinness, Anthony Richard Pope, Terence Derek Prospero, Gregory Paul Winter: Multivalent and multispecific binding proteins, their manufacture and use. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, November 17, 1998: US05837242 (202 worldwide citation)

Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region, the domains being linked but incapable of associating with each other to ...


5
John McCafferty, Anthony Richard Pope, Kevin Stuart Johnson, Henricus Renerus Jacobus Mattheus Hoogenboom, Andrew David Griffiths, Ronald Henry Jackson, Kaspar Philipp Holliger, James David Marks, Timothy Piers Clackson, David John Chiswell, Gregory Paul Winter, Timothy Peter Bonnert: Methods for producing members of specific binding pairs. Medical Research Council, Cambridge Antibody Technology, Marshall O&apos Toole Gerstein Murray & Borun, January 9, 2001: US06172197 (167 worldwide citation)

A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containi ...


6
Gregory Paul Winter, Kevin Stuart Johnson, Andrew David Griffiths, Andrew John Hammond Smith: Methods for producing members of specific binding pairs. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, February 16, 1999: US05871907 (160 worldwide citation)

The invention provides methods and kits for producing specific binding pairs (sbp) members. Populations of polypeptide chain components of sbp members are combined to form libraries of sbps displayed by secreted replicable genetic display packages (rgdp). At least one of the polypeptide chains is ex ...


7
Robin B Hutchison, Robert J Llewellyn, Andre F Viljoen, David Griffiths, David Birch, Iain M Begg: Method for ordering goods, services, and content over an internetwork using a virtual payment account. eCharge Corporation, Christensen O Connor Johnson Kindness PLLC, July 24, 2007: US07249097 (123 worldwide citation)

A virtual payment system for ordering and paying for goods, services and content over an internetwork is disclosed. The virtual payment system comprises a commerce gateway component (52) and a credit processing server component (53). The virtual payment system is a secure, closed system comprising r ...


8
Gregory Paul Winter, Kevin Stuart Johnson, Andrew David Griffiths, Andrew John Hammond Smith: Methods for producing members of specific binding pairs. Medical Research Council, Cambridge Antibody Technology, Marshall O Toole Gerstein Murray & Borun, January 12, 1999: US05858657 (107 worldwide citation)

The invention provides methods and kits for producing specific binding pairs (sbp) members. Populations of polypeptide chain components of sbp members are combined to form libraries of sbps displayed by secreted replicable genetic display packages (rgdp). At least one of the polypeptide chains is ex ...


9
Lawson Alastair David Griffiths, Lightwood Daniel John: Methods for producing antibodies. Celltech R & D, Lawson Alastair David Griffiths, Lightwood Daniel John, THOMPSON John, December 9, 2004: WO/2004/106377 (91 worldwide citation)

The invention relates to a method of obtaining an antibody with a desired function, the method comprising: a) bringing a population of B cells into contact with a capturing agent; b) separating the captured B cells from the uncaptured B cells; c) culturing a plurality of captured B cells wherein sai ...


10
Andrew David Griffiths, Hendricus Renerus Jacobus Mattheus Hoogenboom, James David Marks, John McCafferty, Gregory Paul Winter, Geoffrey Walter Grigg: Production of anti-self antibodies from antibody segment repertoires and displayed on phage. Medical Research Council, Cambridge Antibody Technology, Katten Muchin Zavis Rosenman, July 15, 2003: US06593081 (90 worldwide citation)

Methods are disclosed for the production of human self-antibodies and antibody fragments, which bind human antigens. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface a member of a specific binding pair ...