1
Michael J Costenzo, Bruce E Maryanoff, David F McComsey, Samuel O Nortey: Anticonvulsant pseudofructopyranose sulfamates. Ortho Pharmaceutical Corporation, Ralph R Palo, March 12, 1996: US05498629 (19 worldwide citation)

A compound of the general formula I: ##STR1## is disclosed as a potent anticonvulsant drug. Pharmaceutical compositions and methods of treatment are also disclosed.


2
Han Cheng Zhang, William J Hoekstra, Bruce E Maryanoff, David F McComsey: Indole peptidomimetics as thrombin receptor antagonists. Ortho McNeil Pharmaceutical, Millennium Pharmaceuticals, Gabrial Lopez, Hal B Woodrow, February 22, 2005: US06858577 (16 worldwide citation)

The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angi ...


3
Han Cheng Zhang, Gee Hong Kuo, Bruce E Maryanoff, Hong Ye, David O Neill, Lan Shen, Keith Demarest, Bruce R Conway, David F McComsey: Substituted pyrroline kinase inhibitors. Janssen Pharmaceutica, Yurity Stercho, October 24, 2006: US07125878 (15 worldwide citation)

The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.


4
Han Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F McComsey: Indazolyl-substituted pyrroline compounds as kinase inhibitors. Ortho McNeil Pharmaceutical, Hal B Woodrow, Gabriel Lopez, February 1, 2005: US06849643 (12 worldwide citation)

The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.


5
David F McComsey, William J Hoekstra, Bruce E Maryanoff, Han Cheng Zhang: Indole and indazole urea-peptoids as thrombin receptor antagonists. Ortho McNeil Pharmaceutical, Hal B Woodrow, April 2, 2002: US06365617 (7 worldwide citation)

The invention is directed to novel indole and indazole urea-peptoid compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic condi ...


6
Han Cheng Zhang, Bruce E Maryanoff, David F McComsey, Kimberly White, Hong Ye, Leonard R Hecker, Bruce Conway, Keith Demarest: Substituted pyrrolines as kinase inhibitors. Janssen Pharmaceutica, June 19, 2007: US07232906 (5 worldwide citation)

The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.


7
Han Cheng Zhang, Bruce E Maryanoff, David F McComsey, Kimberly B White: Benzimidazolone peptidometics as thrombin receptor antagonist. OrthoMcNeil Pharmaceutical, October 7, 2003: US06630451 (5 worldwide citation)

The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditi ...


8
Bruce E Maryanoff, David F McComsey, Winston Ho: 3-oxo-pyrido(1,2-a)-benzimidazole-4-carboxyl and 4-oxo-azepino(1,2-a)-benzimidazole-5-carboxyl derivatives useful in treating central system disorders. Ralph R Palo, June 17, 1997: US05639760 (5 worldwide citation)

The present invention is directed to compounds of the following formula I: ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, A, n, X, and Y are as defined hereinafter. The compounds of formula I are useful in treating central nervous system disorders. The compounds are ligands for the BZD bind ...


9
Han Cheng Zhang, Gee Hong Kuo, Bruce E Maryanoff, Hong Ye, David O Neill, Lan Shen, David F McComsey: Substituted pyrroline kinase inhibitors. Janssen Pharmaceutica, April 28, 2009: US07524858 (3 worldwide citation)

The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.


10
Bruce E Maryanoff, Han Cheng Zhang, David F McComsey: Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists. Ortho McNeil Pharmaceutical, May 25, 2004: US06740657 (3 worldwide citation)

The invention is directed to novel aminomethyl-pyrroloquinazoline compounds and pharmaceutical compositions thereof which are useful thrombin receptor or PAR-1 antagonists, methods for production thereof and methods for treating thrombin or PAR-1 mediated disorders.