1
Roger D Tung, Scott L Harbeson, David D Deininger, Mark A Murcko, Govinda R Bhisetti, Luc J Farmer: Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease. Vertex Pharmaceuticals Incorporated, James F Haley, Lisa A Dixon, Fish & Neave, July 24, 2001: US06265380 (85 worldwide citation)

The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be used, either alone or in combination to inhi ...


2
Roger D Tung, Scott L Harbeson, David D Deininger, Mark A Murcko, Govinda R Bhisetti, Luc J Farmer: Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease. Vertex Pharmaceuticals Incorporated, James F Haley Jr, Kyumin K Lee, Fish & Neave, September 9, 2003: US06617309 (65 worldwide citation)

The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be used, either alone or in combination to inhi ...


3
Roger D Tung, Scott L Harbeson, David D Deininger, Mark A Murcko, Govinda R Bhisetti, Luc J Farmer: Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease. Vertex Pharmaceuticals Incorporated, Ropes & Gray, James F Haley Jr, David A Roise, June 17, 2008: US07388017 (49 worldwide citation)

The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be used, either alone or in combination to inhi ...


4
David J Lauffer, Robert J Davies, Dean Stamos, Alexander Aronov, David D Deininger, Ronald Grey Jr, Jinwang Xu, Pan Li, Brian Ledford, Luc Farmer, Randy Scott Bethiel, Dylan Jacobs, Kira McGinty: c-MET protein kinase inhibitors. Vertex Pharmaceuticals incorporated, Daniel A Pearson, January 18, 2011: US07872031 (27 worldwide citation)

The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the tr ...


5
Timothy D Ocain, David D Deininger: Renin inhibitors. American Home Products Corporation, Richard K Jackson, March 10, 1992: US05095119 (24 worldwide citation)

A compound of the formula: ##STR1## wherein A is ##STR2## in which X is .dbd.CH-- or .dbd.N--; R.sup.2 is hydrogen, alkyl, phenyl, benzyl or phenethyl; Y is --CH.sub.2--, --NH-- or --O--; and Z is --H.sub.2 or .dbd.O; B is His, Leu, Ile, Nva, Nle, Ala or Val; and R.sup.1 is hydrogen, alkyl, phenyl o ...


6
Timothy D Ocain, David D Deininger: Pyrrolimidazolones useful as renin inhibitors. American Home Products Corporation, Richard K Jackson, December 24, 1991: US05075451 (23 worldwide citation)

A compound of the formula: ##STR1## wherein A is ##STR2## in which X is .dbd.CH-- or .dbd.N--; R.sup.2 is hydrogen, alkyl, phenyl, benzyl or phenethyl; Y is --CH.sub.2 --, --NH-- or --O--; and Z is --H.sub.2 or .dbd.O; B is His, Leu, Ile, Nva, Nle, Ala or Val; and R.sup.1 is hydrogen, alkyl, phenyl ...


7
Timothy D Ocain, David D Deininger: Renin inhibitors. American Home Products Corporation, Richard K Jackson, November 12, 1991: US05064965 (21 worldwide citation)

A compound of the formula: ##STR1## wherein A is ##STR2## in which X is .dbd.CH-- or .dbd.N--; R.sup.2 is hydrogen, alky, phenyl, benzyl or phenylethyl; Y is --CH.sub.2 --, --NH-- or --O--; and Z is --H.sub.2 or O; b is His, Leu, Ile, Nva, Nle, Ala or Val; and R.sup.1 is hydrogen, alkyl, phenyl or p ...


8
Paul S Charifson, David D Deininger, Anne Laure Grillot, Yusheng Liao, Steven M Ronkin, Dean Stamos, Emanuele Perola, Tiansheng Wang, Arnaud LeTiran, Joseph Drumm: Gyrase inhibitors and uses thereof. Vertex Pharmaceuticals Incorporated, Michael C Badia, August 4, 2009: US07569591 (16 worldwide citation)

The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to me ...


9
Paul S Charifson, David D Deininger, Anne Laure Grillot, Yusheng Liao, Steven M Ronkin, Dean Stamos, Emanuele Perola, Tiensheng Wang, Arnaud LeTiran, Joseph Drumm: Gyrase inhibitors and uses thereof. Vertex Pharmaceuticals Incorporated, Michael C Badia, February 24, 2009: US07495014 (15 worldwide citation)

The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to m ...


10
Paul S Charifson, David D Deininger, Joseph Drumm, Anne Laure Grillot, Yusheng Liao, Patricia Oliver Shaffer, Dean Stamos: Gyrase inhibitors and uses thereof. Vertex Pharmaceuticals Incorporated, Michael C Badia, June 1, 2010: US07727992 (14 worldwide citation)

The present invention relates to compounds which inhibit bacterial gyrase and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for trea ...