1
John P Wikswo, Franz J Baudenbacher, David Cliffel, Frederick R Haselton, Eugene J Leboeuf, Ales Prokop, Randall S Reiserer, Mark A Stremler: Bioreactors with multiple chambers. Vanderbilt University, Morris Manning & Martin, Tim Tingkang Xia Esq, July 12, 2011: US07977089 (10 worldwide citation)

A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liquid medium. The bioreactor further ...


2
David Cliffel, Franz J Baudenbacher, John P Wikswo, Sven Eklund, R Robert Balcarcel, Jonathan M Gilligan: Device and methods for detecting the response of a plurality of cells to at least one analyte of interest. Vanderbilt University, Morris Manning & Martin, Tim Tingkang Xia Esq, May 11, 2010: US07713733 (6 worldwide citation)

An apparatus and methods for detecting at least one analyte of interest either produced or consumed by a plurality of cell. In one embodiment of the present invention, the method includes the steps of providing a housing defining a chamber, placing a plurality of cells in the chamber, and simultaneo ...


3
Franz Baudenbacher, John P Wikswo, R Robert Balcarcel, David Cliffel, Sven Eklund, Jonathan Mark Gilligan, Owen McGuinness, Todd Monroe, Ales Prokop, Mark Andrew Stremler, Andreas Augustinus Werdich: Apparatus and methods for monitoring the status of a metabolically active cell. Vanderbilt University, Morris Manning & Martin, Tim Tingkang Xia Esq, April 27, 2010: US07704745 (5 worldwide citation)

An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the stat ...


4
John P Wikswo, Franz J Baudenbacher, Alex Prokop, Eugene J Leboeuf, Chang Y Chung, David Cliffel, Frederick R Haselton, William H Hofmeister, Charles P Lin, Lisa J McCawley, Randall S Reiserer, Mark A Stremler: Capillary perfused bioreactors with multiple chambers. Vanderbilt University, Morris Manning Martin, Tim Tingkang Xia, May 19, 2009: US07534601 (3 worldwide citation)

A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite ...


5
John F Wikswo, David Cliffel, Eugene J Leboeuf, Randall S Reiserer: Bioreactors with an array of chambers and a common feed line. Vanderbilt University, Tim Tingkang Xia Esq, Morris Manning & Martin, March 6, 2012: US08129179

A bioreactor (200) for cultivating living cells in a liquid medium. In one embodiment, the bioreactor (200) has a substrate (230) having a first surface and an opposite second surface, defining a channel (202) therein, and a plurality of chambers (204) formed in the substrate, wherein each of the pl ...


6
David Cliffel, Franz J Baudenbacher, John P Wikswo, Sven Eklund, R Robert Balcarcel, Jonathan M Gilligan: Device and methods for detecting the response of a plurality of cells to at least one analyte of interest. Morris Manning & Martin, January 20, 2005: US20050014129-A1

An apparatus and methods for detecting at least one analyte of interest either produced or consumed by a plurality of cell. In one embodiment of the present invention, the method includes the steps of providing a housing defining a chamber, placing a plurality of cells in the chamber, and simultaneo ...


7
John P Wikswo, Franz J Baudenbacher, David Cliffel, Frederick R Haselton, Eugene J Leboeuf, Alex Prokop, Randall S Reiserer, Mark A Stremler: Bioreactors with multiple chambers. Vanderbilt University, Morris Manning & Martin, July 27, 2006: US20060166354-A1

A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liquid medium. The bioreactor further ...


8
John P Wikswo, Franz J Baudenbacher, Alex Prokop, Eugene J Leboeuf, Chang Y Chung, David Cliffel, Frederick R Haselton, William H Hofmeister, Charles P Lin, Lisa J McCawley, Randall S Reiserer, Mark A Stremler: Capillary perfused bioreactors with multiple chambers. Morris Manning & Martin, June 29, 2006: US20060141607-A1

A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite ...


9
John P Wikswo, Franz J Baudenbacher, R Robert Balcarcel, Theodore A Bapty, David Cliffel, Sven Eklund, Owen McGuinness, Todd Monroe, Ales Prokop, Mark Andrew Stremler, Andreas Augustinus Werdich, Yang Yuansheng: Apparatus and methods for using biological material to discriminate an agent. Tim Tingkang Xia, Morris Manning & Martin, April 6, 2006: US20060073539-A1

An apparatus and methods for using biological material to discriminate an agent. In one embodiment of the present invention, the method includes the steps of providing at least one cell, exposing at least one cell to an agent, measuring the response of the cell to the agent in terms of a physical qu ...


10
John F Wikswo, David Cliffel, Eugene J Leboeuf, Randall S Reiserer: Bioreactors with an array of chambers and a common feed line. Vanderbilt University, Morris Manning & Martin, May 11, 2006: US20060099705-A1

A bioreactor (200) for cultivating living cells in a liquid medium. In one embodiment, the bioreactor (200) has a substrate (230) having a first surface and an opposite second surface, defining a channel (202) therein, and a plurality of chambers (204) formed in the substrate, wherein each of the pl ...