1
David B Fenske, Pieter R Cullis, Kim Wong, Maurer Norbert, Johanna M Leenhouts, Elisabeth Maurer, Nancy Boman: Ionophore-mediated liposome loading. University of British Columbia, Townsend and Townsend and Crew, November 17, 1998: US05837282 (46 worldwide citation)

Novel methods are provided for loading a weakly basic drug into liposomes utilizing an electoneutral transport system. In these methods, ionophores are utilized with liposomes having a metal ion gradient to facilitate the exchange of metal ions for protons. The transported metal ion will, in some em ...


2
Michael Hope, Pieter R Cullis, David B Fenske, Kim F Wong: Method for loading lipid vesicles. The University of British Columbia, Townsend and Townsend and Crew, July 28, 1998: US05785987 (36 worldwide citation)

Methods for the preparation of stable liposome formulations of protonatable therapeutic agents. The methods involve loading a therapeutic agent into preformed liposomes having a methylamine concentration gradient across the lipid bilayer of the liposomes. These methods provide liposome formulations ...


3
Pieter R Cullis, Tao Chen, David B Fenske, Lorne R Palmer, Kim Wong: Cationic peg-lipids and methods of use. The University of British Columbia, Oppedahl & Larson, February 8, 2005: US06852334 (14 worldwide citation)

The present invention provides cationic-polymer-lipid conjugates (CPLs) such as distal cationic-poly(ethylene glycol)-lipid conjugates which can be incorporated into conventional and stealth liposomes or other lipid-based formulation for enhancing cellular uptake. The CPLs of the present invention c ...


4
Pieter R Cullis, Tao Chen, David B Fenske, Lorne R Palmer, Kim Wong: Cationic peg-lipids and methods of use. The University of British Columbia, Oppedahl And Larson, December 2, 2004: US20040241855-A1

The present invention provides cationic-polymer-lipid conjugates (CPLs) such as distal cationic-poly(ethylene glycol)-lipid conjugates which can be incorporated into conventional and stealth liposomes or other lipid-based formulation for enhancing cellular uptake. The CPLs of the present invention c ...