1
David A Gough, Joseph Y Lucisano, Jon C Armour, Brian D McKean: Complete glucose monitoring system with an implantable, telemetered sensor module. The Regents of the University of California, Brown Martin Haller & Meador, November 3, 1987: US04703756 (952 worldwide citation)

An electrochemical system includes a sensor module suitable for implantation in the body to monitor glucose and oxygen levels therein. The module has two oxygen sensors situated in an oxygen-permeable housing, arranged in a tandem relationship, and recessed in the housing, one sensor being unaltered ...


2
David A Gough: Electrochemical cell sensor for continuous short-term use in tissues and blood. The Regents of the University of California, Brown Martin Haller & Meador, June 9, 1987: US04671288 (906 worldwide citation)

An electrochemical cell sensor for monitoring oxidizable enzyme substrates in biological fluids situated in a housing and suitable for implantation in the body, including at least one oxygen or hydrogen peroxide sensing electrode containing a suitable oxidase enzyme, a reference electrode, and a cou ...


3
David A Gough: Two-dimensional diffusion glucose substrate sensing electrode. The Regents of the University of California, Brown Martin Haller & McClain, January 2, 1990: US04890620 (682 worldwide citation)

Enzyme electrode assembly suitable for sensing physiologically important molecules such as glucose wherein the rate of accessibility of enzyme substrates to the enzyme is differentially regulated by suitably positioning material with selective permeability properties around the sensing region of the ...


4
David A Gough: Transparent multi-oxygen sensor array and method of using same. The Regents of the University of California, Brown Martin Haller & Meador, November 1, 1988: US04781798 (607 worldwide citation)

A transparent electrochemical oxygen sensor for simultaneously determining oxygen concentration at different locations on a biological surface that is capable of being positioned over the region sought to be measured and includes an array of independently functioning oxygen-sensitive electrodes, a c ...


5
David A Gough: Method and membrane applicable to implantable sensor. The Regents of the University of California, Brown Martin Haller & Meador, March 17, 1987: US04650547 (434 worldwide citation)

This invention relates to a novel membrane useful in an electro-chemical, optical or other sensor device and to a method employing the membrane for determining the concentration of large molecule compound such as glucose in an aqueous solution of that compound and a dissolved small molecule substanc ...


6
David A Gough: Method and membrane applicable to implantable sensor. The Regents of the University of California, Brown Martin & Haller, November 27, 1984: US04484987 (399 worldwide citation)

This invention relates to a novel membrane useful in an electro-chemical, optical or other sensor device and to a method employing the membrane for determining the concentration of large molecule compound such as glucose in an aqueous solution of that compound and a dissolved small molecule substanc ...


7
David A Gough: Membrane and electrode structure for implantable sensor. Regents of the University of California, Foley & Lardner, April 13, 2004: US06721587 (340 worldwide citation)

The invention is the design of a biological measuring device for the determination of the concentration of biomolecules (e.g. glucose) in an environment which is designed for implantation into an individual or for use in the context of an external apparatus. The device contains a composite membrane ...


8
David A Gough, Joseph Y Lucisano: Method for increasing the service life of an implantable sensor. The Regents of the University of California, Brown Martin Haller & McClain, November 16, 1999: US05985129 (260 worldwide citation)

Methods are described for extending the service life of implantable sensors having a silver-containing anodic reference electrode maintained at a high impedance, at least one noble metal cathodic working electrode, and at least one noble metal anodic counter electrode maintained at a low impedance, ...


9
Jeffrey H Price, David A Gough: Autofocus system for scanning microscopy. Jeffrey H Price, Gray Cary Ware Freidenrich, August 4, 1998: US05790710 (162 worldwide citation)

Reliable autofocus is required to obtain accurate measurements of fluorescent stained cellular components from a system capable of scanning multiple microscope fields. Autofocus could be performed directly with fluorescence images, but due to photobleaching and destructive fluorescence by-products, ...


10
Jeffrey H Price, David A Gough: Method and means of least squares designed filters for image segmentation in scanning cytometry. Jeffrey H Price, Gray Cary Ware Freidenrich, August 4, 1998: US05790692 (77 worldwide citation)

In an image segmentation system that processes image objects by digital filtration, a digital filter is defined. The digital filter includes a neighborhood operator for processing intensity values of neighborhoods of pixels in a pixel array. A first pixel array is received defining a pixelated image ...