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Dashyant Dhanak, Kenneth Allen Newlander: Azaindole inhibitors of aurora kinases. SmithKline Beecham, Reid S Willis, William R Majarian, Stephen Venetianer, October 16, 2007: US07282588 (18 worldwide citation)

The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.


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Deirdre Mary Bernadette Hickey, Dashyant Dhanak, Colin Andrew Leach, Robert John Ife, David Graham Tew: Azetidinone derivatives for the treatment of atherosclerosis. SmithKline Beecham, James M Kanagy, Charles M Kinzig, June 6, 2000: US06071899 (16 worldwide citation)

Azetidinone derivatives of formula (I) in which R.sup.1 and R.sup.2, which may be the same or different, is each selected from hydrogen or C.sub.(1-8) alkyl; R.sup.3 is C.sub.(1-8) alkyl or C.sub.(3-8) cycloalkyl each of which may be optionally substituted; X is a linker group; Y is an aryl group; a ...


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Deirdre Mary Bernadette Hickey, Dashyant Dhanak, Colin Andrew Leach, Robert John Ife, David Graham Tew: Substituted azetidin-2-ones for treatment of atherosclerosis. SmithKline Beecham, Wayne J Dustman, William T King, Charles M Kinzig, November 23, 1999: US05990102 (16 worldwide citation)

Compounds of formula (I) in which R.sup.1 and R.sup.2, which may be the same or different, is each selected from hydrogen, halogen or C.sub.(1-8) alkyl; R.sup.3 is aryl or aryl C.sub.(1-4) alkyl which may be optionally substituted; X is a linker group; Y is an optionally substituted aryl group; and ...


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Pu Ping Lu, David J Morgans Jr, Bing Yao, Dashyant Dhanak, Steven David Knight: 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use. Cytokinetics, SmithKline Beecham Corporation, Finnegan Henderson Farabow Garrett & Dunner L, May 2, 2006: US07038048 (9 worldwide citation)

Provided herein are certain compounds of Formula I: that can be used to treat diseases of proliferating cells. The compounds are KSP kinesin inhibitors, particularly inhibitors of human KSP.


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Dashyant Dhanak, Timothy F Gallagher, Steven D Knight, Stanley J Schmidt: Sulfonamides. SmithKline Beecham Corporation, Linda E Hall, Stephen Venetianer, Charles M Kinzig, February 1, 2005: US06849635 (9 worldwide citation)

The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.


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Dashyant Dhanak, Steven David Knight, Jian Jin, Richard McCulloch Keenan: Urotensin-II receptor antagonists. SmithKline Beecham Corporation, Linda E Hall, Stephen Venetianer, Charles M Kinzig, April 8, 2003: US06544992 (9 worldwide citation)

The present invention relates to pyrrolyl and pyridyl derivatives, pharmaceutical compositions containing them and their use as inhibitors of urotensin II.


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