51
Carl A Gregory, Darwin J Prockop: Compositions of Mesenchymal Stem Cells to Regenerate Bone. The Texas A&M University System, Drinker Biddle & Reath, September 30, 2010: US20100247494-A1

The present invention encompasses an osteogenic composition comprising mesenchymal stem cells pre-cultured in the presence of an agent that accelerates canonical Wnt signaling therein. Also, provided are osteogenic compositions incorporated into a biocompatible gel. The present invention provides me ...


52
Darwin J Prockop, David G Stokes, S Ausim Azizi: Isolated stromal cells for use in the treatment of diseases of the central nervous system. Philadelphia Health And Education Corporation, Seed Intellectual Property Law Group Pllc, August 27, 2009: US20090214492-A1

Methods of treating a human patient having a disease, disorder or condition of the central nervous system are disclosed. The methods include obtaining a bone marrow sample from a human donor, isolating stromal cells from the bone marrow sample, and administering the isolated stromal cells to the cen ...


53
Darwin J Prockop, Gregory J Block, Shinya Ohkouchi, Hosoon Choi: Mesenchymal stem cells that express increased amounts of anti-apoptotic proteins. September 15, 2011: US20110223138-A1

The invention includes a purified population of mesenchymal stromal cells that have been cultured under conditions, such as having been contacted with an apoptotic cell, to express increased levels of at least one anti-apoptotic protein. Such mesenchymal stem cells may be used to treat diseases, dis ...


54
Darwin J Prockop, Ryang Hwa Lee: Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage. The Texas A&M University System, Drinker Biddle & Reath, November 4, 2010: US20100278790-A1

The present invention provides compositions comprising mesenchymal stem cells (MSCs), and methods for their novel use in the repair of cardiac damage and treatment of inflammatory diseases. The invention also provides methods for using TSG-6 protein that is secreted by MSCs under certain conditions, ...


55
Darwin J Prockop, Ruth F Pereira, Dennis B Leeper, Michael D O Hara, Joseph Kulkosky, Donald Phinney, Alexey Laptev, Jose Caro: Isolated stromal cells and methods of using the same. Thomas Jefferson University, Seed Intellectual Property Law Group Pllc, January 14, 2010: US20100008964-A1

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration ...


56
Darwin J Prockop, Ruth F Pereira, Dennis B Leeper, Michael D O Hara, Joseph Kulkosky, Donald Phinney, Alexey Laptev, Jose Caro: Isolated stromal cells and methods of using the same. August 23, 2012: US20120213752-A1

Isolated stromal cells, containers comprising isolated stromal cells transfected with exogenous DNA, and methods of treating patients suffering from diseases characterized by a bone cartilage or lung defect are disclosed. The methods comprise obtaining a bone marrow sample from a donor, isolating st ...


57
Darwin J Prockop, Ryang Hwa Lee, Min Jeong Seo: Methods for treating diabetes. Tulane University Health Sciences Center, February 2, 2012: US20120027729-A1

Transplantation of multipotent stromal cells (MSCs) into diabetic mice lowers blood sugar, increases blood insulin levels, increases the number and size of islets, and improves renal pathology. Accordingly, the invention provides methods for treating or preventing diabetes by administering isolated ...


58
Darwin J Prockop, Thomas W Bartosh JR, Joni Ylostalo: Spheroidal Aggregates of Mesenchymal Stem Cells. August 30, 2012: US20120219572-A1

The present invention encompasses methods and compositions for reducing inflammation in a mammal. The invention includes a population of mesenchimal stromal cells that possess anti-inflammatory, anti-apoptolic, immune modulatory, and anti-tumorigenic properties.


59
Alain Colige, Charles M Lapiere, Darwin J Prockop: Recombinant N-proteinase and methods and uses thereof. University of Liege, August 6, 2002: US06428998

The present invention relates to novel polynucleotide sequences encoding human N-proteinase, and the polypeptides encoded by such polynucleotide sequences. The present invention further relates to methods for using the polynucleotides encoding human N-proteinase to produce the protein.


60
Darwin J Prockop, Yoshio Hojima, Shi Wu Li, Aleksander Sieron: Recombinant C-proteinase and processes, methods and uses thereof. Thomas Jefferson University, Robins & Pasternak, May 13, 2003: US06562613

The present invention is directed to the isolation and identification of the nucleic acid sequence encoding C-proteinase, the recognition of such protein's activity and applications, and tools, processes, and methods of use thereof.



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