21
Darwin J Prockop, Yoshio Hojima, Shi Wu Li, Aleksander Sieron: Recombinant C-proteinase and processes, methods and uses thereof. FibroGen, Pennie & Edmonds, February 1, 2000: US06020193 (1 worldwide citation)

The present invention is directed to the isolation and identification of the nucleic acid sequence encoding C-proteinase, the recognition of such protein's activity and applications, and tools, processes, and methods of use thereof.


22
Darwin J Prockop, Weiwen Deng: Directed in vitro differentiation of marrow stromal cells into neural cell progenitors. Benjamin Aaron Adler, June 16, 2009: US07547545 (1 worldwide citation)

The invention relates to methods for inducing marrow stromal cells to differentiate into neural cells by way of increasing intracellular levels of cyclic AMP. The invention also encompasses methods of producing a neural cell by causing a marrow stromal cell to differentiate into a neural cell by inc ...


23
Carl A Gregory, Darwin J Prockop: Compositions of mesenchymal stem cells to regenerate bone. The Texas A & M University System, Gardere Wynne Sewell, December 6, 2016: US09511093

The present invention encompasses an osteogenic composition comprising mesenchymal stem cells pre-cultured in the presence of an agent that accelerates canonical Wnt signaling therein. Also, provided are osteogenic compositions incorporated into a biocompatible gel. The present invention provides me ...


24
Robert Rosa, Gavin W Roddy, Darwin J Prockop: Protein therapy for corneal inflammation, epithelial wound healing, and photoreceptor degeneration. Scott & White Healthcare, The Texas A&M University System, Hodgson Russ, June 24, 2014: US08759298

The present invention encompasses methods, compositions, and devices for treating an ocular disease, disorder or condition in a mammal. The invention includes polypeptides that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties, and their application in the ...


25
Robert Rosa, Gavin W Roddy, Darwin J Prockop: Protein therapy for treatment of retinal diseases. Scott & White Healthcare, The Texas A&M University System, Hodgson Russ, July 28, 2015: US09090704

The present invention encompasses methods, compositions, and devices for treating an ocular disease, disorder or condition in a mammal. The invention includes polypeptides that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties, and their application in the ...


26
Ira B Black, Dale L Woodbury, Darwin J Prockop, Emily Schwarz: Differentiation of bone marrow cells into neuronal cells and uses therefor. University of Medicine and Dentistry of New Jersey, Philadelphia Health and Education Corporation, DLA Piper, July 16, 2013: US08486698

The present invention relates to methods of inducing differentiation of mammalian bone marrow stromal cells into neuronal cells by contacting marrow stromal cells with a neuronal differentiation-inducing compounds. Neuronal differentiation-inducing compounds of the invention include anti-oxidants su ...


27
Darwin J Prockop, Andrzej Fertala: Inhibitors of collagen assembly. MCP Hahnemann University, Morgan Lewis & Bockius, October 29, 2002: US06472504

The invention relates to peptides and peptidomimetics which inhibit assembly of human type I collagen. Methods of identifying such peptides and peptidomimetics are also included in the invention.


28
Darwin J Prockop, Joo Youn Oh, Barry Berkowitz, Gavin W Roddy, Robert Rosa: Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases. The Texas A&M University System, Temple Therapeutics, Scott & White Healthcare, Raymond J Lillie, June 23, 2015: US09062103

The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties. The invent ...


29
Darwin J Prockop, Joo Youn Oh, Barry Berkowitz: Adult stem cells/progenitor cells and stem cell proteins for treatment of eye injuries and diseases. The Texas A&M University System, Temple Therapeutics, Raymond J Lillie, January 17, 2017: US09545428

The present invention encompasses methods and compositions for treating an ocular disease, disorder or condition in a mammal. The invention includes a population of mesenchymal stromal cells that possess anti-inflammatory, anti-apoptotic, immune modulatory and anti-tumorigenic properties. The invent ...


30
Darwin J Prockop, Andrzej Fertala: Inhibitors of collagen assembly. Drexel University College of Medicine, Caesar Rivise Bernstein Cohen & Pokotilow, March 28, 2006: US07018803

The invention relates to peptides and peptidomimetics which inhibit assembly of human type I collagen. Methods of identifying such peptides and peptidomimetics are also included in the invention.



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