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Hongyan Guo, Darryl Kato, Thorsten A Kirschberg, Hongtao Liu, John O Link, Michael L Mitchell, Jay P Parrish, Jianyu Sun, James Taylor, Elizabeth M Bacon, Eda Canales, Aesop Cho, Choung U Kim, Jeromy J Cottell, Manoj C Desai, Randall L Halcomb, Scott E Lazerwith, Richard L Mackman, Hyung Jung Pyun, Joseph H Saugier, James D Trenkle, Winston C Tse, William J Watkins, Lianhong Xu: Antiviral compounds. Gilead Sciences, Viksnins Harris & Padys PLLP, January 3, 2012: US08088368 (39 worldwide citation)

The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.


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Hongyan Guo, Darryl Kato, Thorsten A Kirschberg, Evan S Krygowski, John O Link, Michael L Mitchell, Jay P Parrish, James Taylor: Antiviral compounds. Gilead Sciences, Sheppard Mullin Richter & Hampton, March 11, 2014: US08669234 (7 worldwide citation)

The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.


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Elizabeth M Bacon, Jeromy J Cottell, Ashley Anne Katana, Darryl Kato, Evan S Krygowski, John O Link, James Taylor, Chinh Viet Tran, Teresa Alejandra Trejo Martin, Zheng Yu Yang, Sheila Zipfel: Antiviral compounds. Gilead Sciences, Sheppard Mullin Richter & Hampton, Lorna L Tanner, November 5, 2013: US08575135 (6 worldwide citation)

The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.


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Elizabeth M Bacon, Jeromy J Cottell, Ashley Anne Katana, Darryl Kato, Evan S Krygowski, John O Link, James Taylor, Chinh Viet Tran, Teresa Alejandra Trejo Martin, Zheng Yu Yang, Sheila Zipfel: Antiviral compounds. Gilead Pharmasset, Sheppard Mullin Richter & Hampton, December 30, 2014: US08921341 (4 worldwide citation)

The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.


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Elizabeth M Bacon, Jeromy J Cottell, Ashley Anne Katana, Darryl Kato, Evan S Krygowski, John O Link, James Taylor, Chinh Viet Tran, Teresa Alejandra Trejo Martin, Zheng Yu Yang, Sheila Zipfel: Antiviral compounds. Gilead Pharmasset, Sheppard Mullin Richter & Hampton, January 27, 2015: US08940718 (2 worldwide citation)

The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.


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Kevin S Currie, Zhimin Du, Julie Farand, Juan A Guerrero, Ashley A Katana, Darryl Kato, Scott E Lazerwith, Jiayao Li, John O Link, Nicholas Mai, Gregory Notte, Hyung jung Pyun, Michael Sangi, Aaron C Schmitt, Adam J Schrier, Kirk L Stevens, Chandrasekar Venkataramani, William J Watkins, Zheng Yu Yang, Jeff Zablocki, Sheila Zipfel, Jennifer R Lo, Seung H Lee, Zhongdong Zhao, Jeffrey Kropf, Jianjun Xu, Peter Blomgren, Scott A Mitchell, JinMing Xiong, Jayaraman Chandrasekhar: Substituted pyrrolidines as SYK inhibitors. Gilead Sciences, June 28, 2016: US09376441 (2 worldwide citation)

The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein X1, X2, X3, R2, R3, R4, R5, and Y ar ...


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Elizabeth M Bacon, Jeromy J Cottell, Ashley Anne Katana, Darryl Kato, Evan S Krygowski, John O Link, James Taylor, Chinh Viet Tran, Teresa Alejandra Trejo Martin, Zheng Yu Yang, Sheila Zipfel: Antiviral compounds. Gilead Pharmasset, Sheppard Mullin Richter & Hampton, October 13, 2015: US09156823 (1 worldwide citation)

The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.