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Franco Buzzetti, Angelo Crugnola, Dario Ballinari, Felicita Greco: Vinylene-azaindole derivatives. Farmitalia Carlo Erba S R L, Oblon Spivak McClelland Maier & Neustadt, March 14, 1995: US05397787 (105 worldwide citation)

The present invention relates to the compounds of formula (I) ##STR1## wherein one of the groups X.sup.1 to X.sup.4 is N and the others are CH; the rest of the variables are as defined in the specification.


2
Franco Buzzetti, Maria Gabriella Brasca, Antonio Longo, Dario Ballinari: Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors. Pharmacia S p A, Oblon Spivak McClelland Maier & Neustadt P C, November 24, 1998: US05840745 (25 worldwide citation)

Novel hydrosoluble 3-arylidene-2-oxindole derivatives, having tyrosine kinase inhibitor activity, encompassed by general formula (I), wherein m is zero, 1 or 2; A is a bicyclic ring chosen from tetralin, naphthalene, quinoline and indole; R.sup.1 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub ...


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Franco Buzzetti, Maria Gabriella Brasca, Antonio Longo, Dario Ballinari: Aryl and heteroaryl purine compounds. Pharmacia & Upjohn S p A, Oblon Spivak McClelland Maier & Neustadt P C, October 12, 1999: US05965563 (14 worldwide citation)

Novel bicyclic condensed pyrimidine compounds having general formula (I) ##STR1## wherein X is --CH.sub.2 --, --NH--(CH.sub.2).sub.n --, --O--(CH.sub.2).sub.n -- or --S--(CH.sub.2).sub.n -- in which n is zero or 1; A is a 4,5-fused imidazole ring N-substituted by R.sub.3 which is hydrogen, C.sub.1 - ...


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Carlo Battistini, Dario Ballinari, Antonella Ermoli, Sergio Penco, Sergio Vioglio: Substituted indolylmethylene-oxindole analogues as tyrosine kinase inhibitors. Pharmacia & Upjohn S p A, Oblon Spivak McClelland Maier & Neustadt P C, December 15, 1998: US05849710 (13 worldwide citation)

The present invention relates to indol-3-ylmethylene-2-oxindole derivatives which are useful as tyrosine kinase inhibitors. The compounds are suitable for use as anti-proliferative agents, anti-metastatic agents, anti-cancer agents, and in the control of angiogenesis and in inhibiting the developmen ...


6
Franco Buzzetti, Maria Gabriella Brasca, Antonio Longo, Dario Ballinari: Substituted azaindolylidene compounds and process for their preparation. Pharmacia S p A, Oblon Spivak McClelland Maier & Neustadt P C, September 2, 1997: US05663346 (12 worldwide citation)

The present invention relates to compounds useful as tyrosine kinase inhibitors, having the following general formula (I) ##STR1## wherein one of the groups X.sup.1, X.sup.2, X.sup.3, X.sup.4 is N and the others are CH; R is a group of formula (a), (b), (c) or (d) ##STR2## each of R.sup.1 and R.sup. ...


7
Antonino Suarato, Jacqueline Lansen, Michele Caruso, Dario Ballinari, Tiziano Bandiera: Use of anthracyclinone derivatives in amyloidosis. Pharmacia & Upjohn S P A, Oblon Spivak McClelland Maier & Neustadt P C, March 24, 1998: US05731313 (9 worldwide citation)

The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4, and R5, are appropriate substituents. Some compounds of formula (A) are novel. Processes for their preparation and pharmaceutical composition containing them are ...


8
Franco Buzzetti, Antonio Longo, Maria Gabriella Brasca, Fabrizio Orzi, Angelo Crugnola, Dario Ballinari, Mariangela Mariani: Arylidene and heteroarylidene oxindole derivatives and process for their preparation. Farmitalia Carlo Erba S r l, Oblon Spivak McClelland Maier & Neustadt P C, August 12, 1997: US05656654 (6 worldwide citation)

Arylidene and heteroarylidene oxindole derivatives of formula (I) ##STR1## wherein, subject to provisos, Y is a bicyclic ring system chosen from naphthalene, tetralin, quinoline and isoquinoline;


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Franco Buzzetti, Gabriella Maria Brasca, Antonio Longo, Dario Ballinari: Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation. Pharmacia S p A, Oblon Spivak McClelland Maier & Neustadt P C, February 17, 1998: US05719135 (6 worldwide citation)

The present invention relates to compound of formula (I) ##STR1## wherein A is benzene, naphthalene, 5,6,7,8,-tetrahydronaphthalene, quinoline, isoquinoline, indole or 7-azaindole;


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Antonino Suarato, Jacqueline Lansen, Michele Caruso, Dario Ballinari, Tiziano Bandiera: Anthracyclinone derivatives and their use in amyloidosis. Pharmacia & Upjohn S p A, Oblon Spivak McClelland Maier & Neustadt P C, August 1, 2000: US06096888 (6 worldwide citation)

The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4, and R5, are appropriate substituents. Some compounds of formula (A) are novel. Processes for their preparation and pharmaceutical composition containing them are ...