1
Daniel L Kacian, Timothy J Fultz: Nucleic acid sequence amplification methods. Gen Probe Incorporated, Lyon & Lyon, March 21, 1995: US05399491 (528 worldwide citation)

Methods of synthesizing multiple copies of a target nucleic acid sequence autocatalytically under conditions of substantially constant temperature, ionic strength, and pH are provided in which multiple RNA copies of the target sequence autocatalytically generate additional copies. These methods are ...


2
Daniel L Kacian, Diane L McAllister, Sherrol H McDonough, Nanibhushan Dattagupta: Nucleic acid sequence amplification method, composition and kit. Gen Probe Incorporated, Lyon & Lyon, September 10, 1996: US05554516 (231 worldwide citation)

A method, composition and kit for amplifying a target nucleic acid sequence under conditions of substantially constant temperature, ionic strength, and pH and using only a single promoter-primer. To effect the amplification, a supply of a single promoter-primer having a promoter and a primer complem ...


3
Daniel L Kacian, Timothy J Fultz: Nucleic acid sequence amplification methods. Gen Probe Incorporated, Lyon & Lyon, January 2, 1996: US05480784 (137 worldwide citation)

Methods of synthesizing multiple copies of a target nucleic acid sequence autocatalytically under conditions of substantially constant temperature, ionic strength, and pH are provided in which multiple RNA copies of the target sequence autocatalytically generate additional copies. Nucleotide sequenc ...


4
Sherrol H McDonough, Daniel L Kacian, Nanibhushan Dattagupta, Diane L McAllister, Philip W Hammond, Thomas B Ryder: Methods of amplifying nucleic acids using promoter-containing primer sequence. Gen Probe Incorporated, Lyon & Lyon, June 16, 1998: US05766849 (89 worldwide citation)

A method, composition and kit for synthesizing multiple copies of a target nucleic acid sequence autocatalytically under conditions of substantially constant temperature, ionic strength, and pH are provided in which multiple RNA copies of the target sequence autocatalytically generate additional cop ...


5
Nancy L Shen, Daniel L Kacian, James G Putnam, William M Davis: Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification. Gen Probe Incorporated, Carlos A Fisher, September 17, 1996: US05556771 (62 worldwide citation)

Stabilized reverse transcriptase and RNA polymerase compositions for use in nucleic acid amplification. Compositions are provided for the stabilization of one or more enzymes in a single stabilized formulation. Additional compositions incorporate a dried, stabilized enzyme mixture together with nece ...


6
Bruce W Anderson, Nick M Carter, Mordi I Iheme, Shirley J Johnson, Daniel L Kacian, James P Light, Gus G Tseo: Penetrable cap. Gen Probe Incorporated, Charles B Cappellari, April 6, 2004: US06716396 (52 worldwide citation)

The present invention relates to a cap which can form an essentially leak-proof seal with a vessel capable of receiving fluid specimens for clinical analysis and diagnosis. To minimize potentially contaminating contact between the fluid specimen and humans or the environment, the present invention f ...


7
Thomas B Ryder, Daniel L Kacian: Amplification of nucleic acids from mononuclear cells using iron complexing and other agents. Gen Probe Incorporated, Lyon & Lyon, June 17, 1997: US05639599 (49 worldwide citation)

Method and kit for the preparation of nucleic acid, such as for amplification. The nucleic acid may be prepared by centrifuging a sample of whole cells, particularly mononuclear cells, with an appropriate centrifugation medium so as to separate desired cells from non-desired cells, then removing and ...


8
Bruce W Anderson, Nick M Carter, Mordi I Iheme, Daniel L Kacian: Collection device. Gen Probe Incorporated, Charles B Cappellari, December 18, 2007: US07309469 (42 worldwide citation)

A collection device comprising an open-ended vessel for receiving and holding a fluid substance and a cap configured to position a specimen retrieval device along an inner surface of the vessel when the cap is fixedly associated the vessel.


9
Bruce W Anderson, Nick M Carter, Mordi I Iheme, Shirley J Johnson, Daniel L Kacian, James P Light II, Gus G Tseo: Method for removing a fluid substance from a collection device. Gen Probe Incorporated, Charles B Cappellari, October 19, 2004: US06806094 (34 worldwide citation)

The present invention relates to a cap which can form an essentially leak-proof seal with a vessel capable of receiving fluid specimens for clinical analysis and diagnosis. To minimize potentially contaminating contact between the fluid specimen and humans or the environment, the present invention f ...


10
Daniel L Kacian, Mark R Kennedy, Nick M Carter: Penetrable cap. Gen Probe Incorporated, Charles B Cappellari, April 6, 2010: US07691332 (33 worldwide citation)

A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invent ...