1
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Human antibodies derived from immunized xenomice. Abgenix, James F Haley Jr, Jane T Gunnison, Fish & Neave, June 13, 2000: US06075181 (548 worldwide citation)

Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipula ...


2
Daniel J Capon, Laurence A Lasky: Hybrid immunoglobulins. Genentech, Ginger R Dreger, Carolyn R Adler, May 26, 1992: US05116964 (534 worldwide citation)

Immunoglobulin fusion polypeptides are provided, together with methods for making and using them, and nucleic acids encoding them. These polypeptides are useful as cell surface adhesion molecules and ligands, and are useful in therapeutic or diagnostic compositions and methods.


3
Raju Kucherlapati, Aya Jakobovits, Daniel G Brenner, Daniel J Capon, Sue Klapholz: Human antibodies derived from immunized xenomice. Abgenix, James F Haley Jr, Jane T Gunnison, Fish & Neave, November 21, 2000: US06150584 (441 worldwide citation)

Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed ...


4
Raju Kucherlapati, Aya Jakobovits, Sue Kalpholz, Daniel G Brenner, Daniel J Capon: Generation of xenogeneic antibodies. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, September 5, 2000: US06114598 (335 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


5
Raju Kucherlapati, Aya Jakobovits, Sue Klapholz, Daniel G Brenner, Daniel J Capon: Generation of Xenogenetic antibodies. Abgenix, James F Haley Jr Esq, Jane T Gunnison Esq, Fish & Neave, December 19, 2000: US06162963 (291 worldwide citation)

The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunctio ...


6
Daniel J Capon, Laurence A Lasky: Hybrid immunoglobulins. Genentech, Ginger R Dreger, June 27, 1995: US05428130 (280 worldwide citation)

Novel polypeptides are provided, together with methods for making and using them, and nucleic acids encoding them. These polypeptides are useful as cell surface adhesion molecules and ligands, and are useful in therapeutic or diagnostic compositions and methods.


7
Daniel J Capon, Laurence A Lasky: Lymphocyte homing receptor/immunoglobulin fusion proteins. Genentech, Ginger R Dreger, July 6, 1993: US05225538 (244 worldwide citation)

Novel polypeptides are provided, together with methods for making and using them, and nucleic acids encoding them. These polypeptides are useful as cell surface adhesion molecules and ligands, and are useful in therapeutic or diagnostic compositions and methods.


8
Daniel J Capon, Arthur Weiss, Brian A Irving, Margo R Roberts, Krisztina Zsebo: Chimeric chains for receptor-associated signal transduction pathways. Cell Genesys, The Regents of the University of California, Bertram I Rowland, October 25, 1994: US05359046 (195 worldwide citation)

Chimeric proteins and DNA sequence encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathwa ...


9
Daniel J Capon, Timothy J Gregory: CD4 adheson variants. Genentech, Ginger R Dreger, Janet E Hasak, August 9, 1994: US05336603 (168 worldwide citation)

Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amino acid sequence variations are introduced into adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered f ...


10
Daniel J Capon, Laurence A Lasky: Recombinant DNA encoding hybrid immunoglobulins. Genentech, Ginger R Dreger, May 7, 1996: US05514582 (148 worldwide citation)

Novel polypeptides are provided, together with methods for making and using them, and nucleic acids encoding them. These polypeptides are useful as cell surface adhesion molecules and ligands, and are useful in therapeutic or diagnostic compositions and methods.