1
Petpiboon Prasit, Daniel Guay, Zhaoyin Wang, Serge Leger, Michel Therien: Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2. Merck Frosst Canada, Curtis C Panzer, David L Rose, May 28, 1996: US05521213 (155 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encomp ...


2
Daniel Guay, Chun Sing Li: 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2. Merck Frosst Canada, Curtis C Panzer, David L Rose, February 18, 1997: US05604260 (149 worldwide citation)

The Compound of Formula I and pharmaceutically acceptable salts thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed.


3
Cheuk Kun Lau, Cameron Black, Daniel Guay, Jacques Yves Gauthier, Yves LeBlanc, Patrick Roy, Yves Ducharme, Pierre Hamel: N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, June 17, 1997: US05639780 (140 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


4
Cheuk K Lau, Cameron Black, Daniel Guay, Jacques Y Gauthier, Yves LeBlanc, Patrick Roy, Yves Ducharme, Pierre Hamel: N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, February 18, 1997: US05604253 (136 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encomp ...


5
W Cameron Black, Chun Sing Li, Daniel Guay, Petpiboon Prasit, Patrick Roy: Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase. Merck Frosst Canada, Curtis C Panzer, David L Rose, April 25, 1995: US05409944 (113 worldwide citation)

Disclosed are compounds of Formula I useful in the treatment of cyclooxygenase mediated diseases such as pain, fever and inflammation of a variety of conditions including rheumatic fever, symptoms associated with influenza or other viral infections, common cold, low back and neck pain, dysmenorrhea, ...


6
Michel Gallant, Yves Gareau, Daniel Guay, Marc Labelle, Petpiboon Prasit: Indole derivatives with affinity for the cannabinoid receptor. Merck Frosst Canada, Sylvia A Ayler, Mark R Daniel, July 2, 1996: US05532237 (73 worldwide citation)

Disclosed are indole derivatives having activity on the cannabinoid receptors and the methods of their preparation. The compounds are useful for lowering ocular intra ocular pressure and treating glaucoma because of the activity on the cannabinoid receptor.


7
Daniel Guay, Yves Girard, Yves Ducharme, Marc Blouin, Pierre Hamel, Mario Girard: Tri-aryl ethane derivatives as PDE IV inhibitors. Merck Frosst Canada, Curtis C Panzer, David L Rose, January 20, 1998: US05710170 (37 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). ##STR1## The invention also encompasses certain pharmaceutical ...


8
Michel L Belley, Serge Leger, Marc Labelle, Patrick Roy, Yi B Xiang, Daniel Guay: Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists. Merck Frosst Canada, Mollie M Yang, David L Rose, October 15, 1996: US05565473 (37 worldwide citation)

Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, h ...


9
Cameron Black, Mario Girard, Daniel Guay, Zhaoyin Wang: Diphenyl stilbenes as prodrugs to COX-2 inhibitors. Merck Frosst Canada, Richard C Billups, David L Rose, March 31, 1998: US05733909 (34 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


10
Robert Schulz, Guy Lalande, Jacques Huot, Marie Chantal Denis, Guoxian Liang, Andre Van Neste, Daniel Guay, Jean Pol Dodelet: Leached nanocrystalline materials process for manufacture of the same, and use thereof in the energetic field. Hydro Quebec, Foley & Lardner, February 16, 1999: US05872074 (24 worldwide citation)

Leached nanocrystalline materials having a high specific surface are particularly useful for storing hydrogen or as catalysts or electrocatalysts in the manufacture electrodes, especially for fuel cells. Such materials can be manufactured by preparing a nanocrystalline material consisting of a metas ...