1
Daniel G Anderson, David C England, Alwin S Milian Jr: Preparation of fluorocarbonyl compounds. E I Du Pont de Nemours and Company, James A Costello, November 2, 1982: US04357282 (99 worldwide citation)

Fluorinated carbonyl compounds are prepared by contacting a fluorinated methyl or ethyl ether containing at least one methoxylated carbon atom-containing group selected from: --CF.sub.2 OR.sup.3, .dbd.CFOR.sup.3, ##STR1## wherein R.sup.3 is CH.sub.3 or C.sub.2 H.sub.5, with a catalyst selected from:


2
Robert S Langer, David M Lynn, David Putnam, Mansoor M Amiji, Daniel G Anderson: Biodegradable poly(β-amino esters) and uses thereof. Massachusetts Institute of Technology, Brenda Herschbach Jarrell, C Hunter Baker, Choate Hall & Stewart, February 14, 2006: US06998115 (61 worldwide citation)

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably b ...


3
Robert S Langer, David M Lynn, David Putnam, Mansoor M Amiji, Daniel G Anderson: Biodegradable poly(beta-amino esters) and uses thereof. Massachusetts Institute of Technology, Wolf Greenfield & Sacks P C, C Hunter Baker, October 15, 2013: US08557231 (52 worldwide citation)

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably b ...


4
Daniel G Anderson, David M Lynn, Akin Akinc, Robert S Langer: Biodegradable poly(β-amino esters) and uses thereof. Massachusetts Institute of Technology, The United States of Americas represented by the Secretary of the Army, Choate Hall & Stewart, C Hunter Baker, September 23, 2008: US07427394 (45 worldwide citation)

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably b ...


5
Gregory T Zugates, Andreas Zumbuehl, Robert S Langer, Daniel G Anderson: End-modified poly(beta-amino esters) and uses thereof. Massachusetts Institute of Technology, Wolf Greenfield & Sacks P C, C Hunter Baker, Robin A Weatherhead, December 6, 2011: US08071082 (25 worldwide citation)

Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polyme ...


6
Robert S Langer, David M Lynn, David Putnam, Mansoor M Amiji, Daniel G Anderson: Biodegradable poly(beta-amino esters) and uses thereof. Massachusetts Institute of Technology, Wolf Greenfield & Sacks P C, C Hunter Baker, Robin A Weatherhead, October 16, 2012: US08287849 (21 worldwide citation)

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably b ...


7
Daniel G Anderson, Andreas Zumbuehl, Elizaveta Sergeyevna Leshchiner, Robert S Langer, Michael Goldberg: Amine-containing lipids and uses thereof. Massachusetts Institute of Technology, Wolf Greenfield & Sacks P C, C Hunter Baker, Wei Zhang, April 14, 2015: US09006487 (9 worldwide citation)

Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These ...


8
Steven R Little, David M Lynn, Daniel G Anderson, Robert S Langer: pH triggerable polymeric particles. Massachusetts Institute of Technology, Wolf Greenfield & Sacks P C, C Hunter Baker, May 17, 2011: US07943179 (1 worldwide citation)

A drug delivery system comprising pH triggerable particles is described. The pH triggerable particles comprise and agent(s) to be delivered, which is encapsulated in a matrix comprising a pH trigger agent and a polymer. Agents including nucleic acids may be delivered intracellularly using the invent ...


9
Virginia Spanoudaki, Daniel G Anderson, Robert S Langer: Nanowire FET imaging system and related techniques. Daly Crowley Mofford & Durkee, May 15, 2018: US09972649

A sensor comprises a substrate; an array of nanowire field effect transistors (NWFETs) formed in said substrate, each of the NWFETs having source, drain and gate terminals; a nanowire coupled between the source terminal and the drain terminal of each NWFET; and a layer of radiation sensitive materia ...


10
Minglin Ma, Daniel G Anderson, Robert S Langer, Omid Veiseh, Joshua Charles Doloff, Delai Chen, Christian J Kastrup, Arturo Jose Vegas: Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates. Massachusetts Institute of Technology, Pabst Patent Group, January 8, 2019: US10172791

Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of t ...