1
Daniel A Grande, Paul A Lucas: Mesenchymal stem cells for cartilage repair. Morphogen Pharmaceuticals, North Shore University Hospital Research Corporation, Klauber & Jackson, May 25, 1999: US05906934 (380 worldwide citation)

It has been discovered that mesenchymal stem cells (MSCs) in a polymeric carrier implanted into a cartilage and/or bone defect will differentiate to form cartilage and/or bone, as appropriate. Suitable polymeric carriers include porous meshes or sponges formed of synthetic or natural polymers, as we ...


2
Daniel A Grande: Technique for healing lesions in cartilage. Michael Ebert, July 11, 1989: US04846835 (335 worldwide citation)

A grafting technique entailing the transplantation of chondrocytes for promoting the healing of lesions in articular cartilage, use being made for this purpose of in vitro autologous cultured chondrocytes prior to transplantation. The chondrocytes are preferably seeded in a three-dimensional collage ...


3
Robert E Schwartz, Daniel A Grande: Cartilage repair unit. DePuy Orthopaedics, Barnes & Thornburg, June 26, 2001: US06251143 (309 worldwide citation)

A bio-absorbable cartilage repair system is provided for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent health ...


4
Daniel A Grande, Paul A Lucas: Mesenchymal stem cells for cartilage repair. MorphoGen Pharmaceuticals, Klauber & Jackson, April 10, 2001: US06214369 (237 worldwide citation)

It has been discovered that mesenchymal stem cells (MSCs) in a polymeric carrier implanted into a cartilage and/or bone defect will differentiate to form cartilage and/or bone, as appropriate. Suitable polymeric carriers include porous meshes or sponges formed of synthetic or natural polymers, as we ...


5
Robert E Schwartz, Daniel A Grande: Cartilage repair unit. DePuy Orthopaedics, Barnes & Thornburg, October 22, 2002: US06468314 (165 worldwide citation)

A bio-absorbable cartilage repair system is provided for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent health ...


6
Arnold S Breitbart, Daniel A Grande: Tissue-engineered bone repair using cultured periosteal cells. North Shore University Hospital Research Corporation, Arnall Golden & Gregory, December 23, 1997: US05700289 (117 worldwide citation)

Periosteal cells have been grown in cell culture and have been shown to have an osteoblastic phenotype, with production of osteocalcin and glycosaminoglycan. When seeded into polymeric implants, repair of critical size cranial defects was demonstrated and was confirmed by histology, biochemical assa ...


7
Arnold S Breitbart, Daniel A Grande, James M Mason: Genetic engineering of cells to enhance healing and tissue regeneration. North Shore Long Island Jewish Research Institute, Holland & Knight, June 4, 2002: US06398816 (24 worldwide citation)

A method for enhancing and/or increasing the efficiency of repair of tissues, primarily bone or cartilage, using genetically engineered cells has been developed. In the preferred embodiment, mesenchymal stem cells are isolated from periosteum tissue, and transfected with the gene encoding a growth f ...


8
Daniel A Grande, James M Mason: Bioactive scaffolds. The Feinstein Institute For Medical Research, Amster Rothstein & Ebenstein, July 28, 2015: US09089117 (1 worldwide citation)

Provided are tissue scaffolds colonized by vertebrate cells expressing a transgenic bioactive molecule, where the vertebrate cells are unable to undergo mitosis. Also provided are methods of growing tissue in a mammal and methods of delivering a transgenic bioactive molecule to a tissue of a mammal, ...


9
Daniel A Grande, James M Mason, Arnold S Breitbart: Bioactive scaffolds. The Feinstein Institute for Medical Research, Amster Rothstein & Ebenstein, May 16, 2017: USRE046402

Provided are tissue scaffolds colonized by vertebrate cells expressing, a transgenic bioactive molecule, where the vertebrate cells are unable to undergo mitosis. Also provided are methods of growing tissue in a mammal and methods of delivering a transgenic bioactive molecule to a tissue of a mammal ...


10
Robert E Schwartz, Daniel A Grande: Cartilage repair unit. Barnes & Thornburg, July 26, 2001: US20010010023-A1

A bio-absorbable cartilage repair system is provided for regenerating damaged or destroyed articular cartilage on a joint surface of a bone by establishing a chondrogenic growth-supporting matrix between an area of damaged or destroyed articular cartilage that has been removed and an adjacent health ...