1
Jan M R Balzarini, Erik D A De Clercq, Antonin Holy, Dana Hockova: Phosphonate substituted pyrimidine compounds and methods for therapy. Institute of Organic Chemistry, Biochemistry of the Academy of Sciences of the Czech Republic, Mark L Bosse, October 3, 2006: US07115592 (4 worldwide citation)

Novel compounds are provided having formula (I) where R1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).


2
Jan M R Balzarini, Erik D A De Clercq, Antonin Holy, Dana Hockova: Novel compounds and methods for therapy. Institute Of Organic Chemistry, Biochemistry Academy Of Sciences Of The Czech Republic, Rega Stichting Vzw, Mark Bosse, Gilead Sciences, October 26, 2006: US20060241081-A1

Novel compounds are provided having formula (I) where R1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).


3
Jan MR Balzarini, Erik D A De Clercq, Antonin Holy, Dana Hockova: Novel compounds and methods for therapy. Institute of Organic Chenistry and Biochemistry Academyof Sciences of the Czech Republic, KU Leuven Research and Development, Mark Bosse, Gilead Sciences, April 7, 2005: US20050075318-A1

Novel compounds are provided having formula (I) where R1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).


4

5
John De Jersey, Luke William Guddat, Dana Hockova, Dianne Therese Keough: 6-oxopurine phosphoribosyltransferase inhibitors. THE UNIVERSITY OF QUEENSLAND, INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR V V I, Nixon & Vanderhye P C, December 1, 2015: US09200020

The invention relates to compounds which are useful as inhibitors of 6-oxopurine phosphoribosyltransferases such as hypoxanthine-guanine-(xanthine) phosphoribosyltransferase (HG(X)PRT).