1
Charles D Kelman, Dale P DeVore: Human collagen processing and autoimplant use. Darby & Darby, November 13, 1990: US04969912 (136 worldwide citation)

Production of a chemically modified, crosslinkable, telopeptide-containing, naturally crosslinked, solubilized collagen from tissue obtained from a sole human donor, for implanting in the same donor, by chemically modifying the tissue, e.g. by acylation and/or esterification, to form an autoimplanta ...


2
Charles D Kelman, Dale P DeVore: Human collagen processing and autoimplant use. Autogenesis Technologies, Darby & Darby, July 26, 1994: US05332802 (108 worldwide citation)

Production of a chemically modified, crosslinkable, telopeptide-containing, naturally crosslinked, solubilized collagen from tissue obtained from a sole human donor, for implanting in the same donor, by chemically modifying the tissue, e.g. by acylation and/or esterification, to form an autoimplanta ...


3
Charles D Kelman, Dale P DeVore: Non-biodegradable two phase corneal implant and method for preparing same. Autogenesis Technologies, Darby & Darby, November 26, 1991: US05067961 (104 worldwide citation)

The present invention provides a non-biodegradable corneal implant comprising (1) a polymerized transparent collagenous core having acylated amine or esterified carboxyl groups, and (2) a polymerized periphery surrounding the core, the periphery comprising fibrous collagen, e.g., Type I, being in th ...


4
Charles D Kelman, Dale P DeVore: Method of making intraocular lenses with injectable collagen-based compositions. Autogenesis Technologies, Darby & Darby, December 19, 1995: US05476515 (99 worldwide citation)

Injectable collagen-based compositions can be used in methods to fill a lens capsular sac, following lens extraction procedures, to form a new intraocular lens. Purified soluble or partially fibrillar collagen may be modified with acylating agents, sulfonating agents or combinations thereof to form ...


5
Charles D Kelman, Dale P DeVore: Collagen-based adhesives and sealants and methods of preparation and use thereof. Autogenesis Technologies, Darby & Darby, June 15, 1993: US05219895 (92 worldwide citation)

Collagen-based compositions as adhesives and sealants for medical use and preparation thereof are described. Prior to polymerization, soluble or partially fibrillar collagen monomers in solution are chemically modified with an acylating agent, sulfonating agent or a combination of the foregoing. The ...


6
Charles D Kelman, Dale P DeVore: Method for bonding soft tissue with collagen-based adhesives and sealants. Autogenesis Technologies, Darby & Darby, October 11, 1994: US05354336 (90 worldwide citation)

The present invention relates to a method for bonding soft tissues. The method comprises the steps of (a) applying a polymerizable collagen composition onto at least portion of a surface of at least one of a first tissue and a second tissue, (b) exposing the polymerizable collagen composition to an ...


7
Dale P Devore, Charles Putnam, James M Pachence: Methods and products for sealing a fluid leak in a tissue. Testa Hurwitz & Thibeault, February 6, 2001: US06183498 (87 worldwide citation)

Methods and products for rapidly sealing a fluid leak in a tissue are provided. A polymerizable protein is applied to a tissue having an opening which creates a fluid leak in the tissue, in order to seal the opening. The tissue area and opening coated with the polymerizable protein are exposed to an ...


8
Dale P DeVore, Robert A Scherrer, Matthew T Scholz: Viscoelastic collagen solution for ophthalmic use and method of preparation. Minnesota Mining and Manufacturing Company, Donald M Sell, James A Smith, Jennie G Boeder, December 15, 1987: US04713446 (83 worldwide citation)

Chemically-modified collagen is prepared by reacting native collagen with a di or tri-carboxylic acid halide, di or tri-sulfonyl halide, di or tri-anhydride, or di or tri-reactive active ester coupling agent. The reaction is done in a controlled manner so that the degree of cross-linking is limited. ...


9
Charles D Kelman, Dale P Devore: Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom. Autogenesis Technologies, Darby & Darby, April 13, 1993: US05201764 (79 worldwide citation)

The present invention provides a biologically compatible collagenous reaction product comprising ethylenically unsaturated or polymeric substituted collagen, the monomeric substituents being essentially free of nitrogen, e.g., methacrylate, styrene, polyvinyl, ethylene. The collagenous reaction prod ...


10
Charles D Kelman, Dale P DeVore: Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom. Autogenesis Technologies, Darby & Darby, April 14, 1992: US05104957 (67 worldwide citation)

The present invention provides a biologically compatible collagenous reaction product comprising ethylenically unsaturated or polymeric substituted collagen, the monomeric substituents being essentially free of nitrogen, e.g., methacrylate styrene, polyvinyl, ethylene. The collagenous reaction produ ...