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Liversidge Gary G, Cundy Kenneth C, Bishop John F, Czekai David A: Surface modified drug nanoparticles.. Sterling Winthrop, August 19, 1992: EP0499299-A2 (146 worldwide citation)

Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and dispersions conta ...


2
Liversidge Gary G, Cundy Kenneth C, Bishop John F, Czekai David A: X-ray contrast compositions useful in medical imaging.. Sterling Winthrop, August 12, 1992: EP0498482-A2 (55 worldwide citation)

An X-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than 400 nm, and a pharmace ...


3
Mcgurk Simon L, Czekai David A: Gel-stabilized nanoparticulate active agent compositions. Elan Pharma International, Mcgurk Simon L, Czekai David A, SIMKIN Michele M à, January 6, 2005: WO/2005/000265 (5 worldwide citation)

Disclosed is a solid or semi-solid gelatin nanoparticulate active agent dosage form comprising at least one nanoparticulate active agent and at least one glel forming substance which exhibits gelation sufficient to retain excess water in the solid or semi-solid gelatin form. The active agent particl ...


4
Czekai David A, Reed Robert G: Apparatus for sanitary wet milling. Elan Pharma Int, December 19, 2007: EP1867394-A2 (1 worldwide citation)

Improved cleanability and contamination prevention are provided in a wet milling apparatus (1) for the production of pharmaceutical grade milled products. The advantages are provided by a milling agitator (40) that is characterized by a smooth, seamless agitating surface, without crevices or seams w ...


5
Czekai David A, Reed Robert G: Apparatus for sanitary wet milling. Elan Pharma Int, May 28, 2003: EP1313564-A1

Improved cleanability and contamination prevention are provided in a wet milling apparatus (1) for the production of pharmaceutical grade milled products. The advantages are provided by a milling agitator (40) that is characterized by a smooth, seamless agitating surface, without crevices or seams w ...


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Liversidge Gary G, Cundy Kenneth C, Bishop John F, Czekai David A: Nanoparticules de medicament modifie en surface, Surface modified drug nanoparticles. Sterling Winthrop, Elan Pharma International, FETHERSTONHAUGH & CO, March 18, 2003: CA2059432

Dispersible particles consisting essentially of acrystalline drug substance having a surface modifier adsorbedon the surface thereof in an amount sufficient to maintain aneffective average particle size of less than about 400 nm,methods for the preparation of such particles and dispersionscontaining ...


7
Czekai David A, Seaman Larry P: Methode continue pour moudre des substances pharmaceutiques, Continuous method of grinding pharmaceutical substances. Nanosystems, Elan Pharma International, SMART & BIGGAR, November 30, 1995: CA2190134

A continuous method of preparing submicron particles of a therapeutic or diagnos tic agent comprises the steps of continuously introducing the agent and rigid grinding media into a milling chamber, contactin g the agent with the grinding media while in the chamber to reduce the particle sire of the ...


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Czekai David A, Seaman Larry P: Procede de broyage de substances pharmaceutiques, Method of grinding pharmaceutical substances. Nanosystems, Elan Pharma International, SMART & BIGGAR, November 30, 1995: CA2190966

A method of preparing submicron particles of a therapeutic or diagnostic agent w hich comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method provides extr ...


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Czekai David A, Reed Robert G: Appareil pour concassage humide hygienique, Apparatus for sanitary wet milling. Elan Pharma International, Elan Pharma International, FETHERSTONHAUGH & CO, June 30, 2009: CA2406696

Improved cleanability and contamination prevention are provided in a wet milling apparatus (1) for the production of pharmaceutical grade milled products. The advantages are provided by a milling agitator (40) that is characterized by a smooth, seamless agitating surface, without crevices or seams w ...


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