1
Burnett Duane A, Clader John W, Thiruvengadam Tiruvettipuram K, Tann Chou Hong, Lee Junning, Mcallister Timothy, Colon Cesar, Barton Derek H R, Breslow Ronald, Dugar Sundeep, Vaccaro Wayne: Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof.. Schering, January 27, 1993: EP0524595-A1 (40 worldwide citation)

Novel compounds of the formula wherein A is -CH=CH-B; -C IDENTICAL C-B; -(CH2)p-X-B, wherein p is 0-2 and X is a bond, -NH- or-S(O)0-2; optionally substituted heteroaryl or benzofused heteroaryl; -C(O)-B; or wherein k is 1-2; D is B'-(CH2)mC(O)-, wherein m is 1-5; B'-(CH2)q-, wherein q is 2-6; B'-(C ...


2
Fu Xiaoyong, Thiruvengadam Tiruvettipuram K, Tann Chou Hong, Lee Junning, Colon Cesar: Process for preparing delta 9,11 and 21-chloro corticosteroids. Schering, March 19, 1997: EP0763054-A1 (10 worldwide citation)

Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO2Cl2 and imidazole, or PPh3 and CCl4. The disclosed process selectively forms DELTA 9,11 steroids from either 11- alpha - or 11- beta -hydroxy steroids, and can also be used for the o ...


3
Fu Xiaoyong, Thiruvengadam Tiruvettipuram K, Tann Chou Hong, Lee Junning, Colon Cesar: Process for preparing delta 9,11 and 21-chloro corticosteroids. Schering, January 5, 2000: EP0969011-A2 (7 worldwide citation)

Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO2Cl2 and imidazole, or PPh3 and CCl4. The disclosed process selectively forms DELTA steroids from either 11- alpha - or 11- beta -hydroxy steroids, and can also be used for the one-st ...


4
Tann Chou Hong, Thiruvengadam Tiruvettipuram K, Chiu John Sze Hung, Colon Cesar: Process for preparing netilmicin.. Schering, April 22, 1987: EP0219093-A2 (1 worldwide citation)

A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2" positions, and optionally at the 4" position, converting the 1-amino substituents to a 1-N-imino substituent, converting the imino to an ethylamino, ...


5
Burnett Duane A, Clader John W, Thiruvengadam Tiruvettipuram K, Tann Chou Hong, Lee Junning, Mcallister Timothy, Colon Cesar, Barton Derek H R, Breslow Ronald, Dugar Sundeep, Vaccaro Wayne: Composes beta-lactame substitues utilises comme agents hypocholesterolemiants et procedes pour leur preparation, Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof. Schering Corporation, Schering Corporation, OGILVY RENAULT SENCRLSRL, February 4, 1993: CA2114007 (1 worldwide citation)

Novel compounds of formula (I) wherein A is -CH = CH-B; -C .ident. C-B; -(CH2)p-X-B, wherein p is 0-2 and X is a bond, -NH- or -S(O)0-2-; optionally substituted heteroaryl or benzofused heteroaryl; -C(O)-B; or (Ia), wherein k is 1-2; D is B'-(CH2)m C(O)-, wherein m is 1-5; B'-(CH2)q-, wherein q is 2 ...


6
Thiruvengadam Tiruvettipuram K, Fu Xiaoyong, Tann Chou Hong, Mcallister Timothy L, Chiu John S, Colon Cesar: Process for the synthesis of azetidinones. Schering, October 4, 2001: EP1137634-A1 (1 worldwide citation)

This invention provides a process for preparing the hypocholesterolemic compound (I) comprising: (a) reacting p-fluorobenzoylbutyric acid with pivaloyl chloride and acylating the product with a chiral auxiliary to obtain a ketone of formula (IV); (b) reducing the ketone of formula (IV) in the presen ...


7
Fu Xiaoyong, Thiruvengadam Tiruvettipuram K, Tann Chou Hong, Lee Junning, Colon Cesar: Process for preparing delta 9,11 and 21-chloro corticosteroids. Schering, January 5, 2000: EP0969012-A2

Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO2Cl2 and imidazole, or PPh3 and CCl4. The disclosed process selectively forms DELTA steroids from either 11- alpha - or 11- beta -hydroxy steroids, and can also be used for the one-st ...


8
Tann Chou Hong, Thiruvengadam Tiruvettipuram K, Chiu John Sze Hung, Colon Cesar, Green Michael D: Improved process for preparing isepamicin.. Schering, January 2, 1991: EP0405820-A2

An improved process for converting gentamicin B to isepamicin comprising forming 3,6 min -di-N-formylgentamicin B, acylating the 1-amino group with an N-protected (S)-isoserine compound and removing all the blocking groups under conditions which result in high yields of isepamicin. A novel formylati ...


9
Tann Chou Hong, Thiruvengadam Tiruvettipuram K, Chiu John Sze Hung, Colon Cesar: Process for preparing netilmicin.. Schering, October 28, 1987: EP0242385-A1

A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2" positions, and optionally at the 4" position, converting the 1-amino substituents to a 1-N-imino substituent, converting the imino to an ethylamino, ...


10
Tann Chou Hong, Thiruvengadam Tiruvettipuram K, Chiu John Sze Hung, Colon Cesar, Green Michael D: N-protected-(s)-isoserine compounds.. Schering, June 16, 1993: EP0547031-A1

Novel isoserine compounds such as N; O-diformyl-(S)-isoserine and N-formyl-(S)-isoserine are described and used in a process for converting gentamicin B to isepamicin. Active esters are formed by reaction of the isoserine compounds with N-hydroxybenzotriazole, N-hydroxysuccinimide, imidazole, N-hydr ...