1
Jacques Y Gauthier, Cheuk K Lau, Yves LeBlanc, Chun Sing Li, Patrick Roy, Michel Therien, Zhaoyin Wang: Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents. Merck Frosst Canada, Curtis C Panzer, David L Rose, September 3, 1996: US05552422 (167 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encomp ...


2
Daniel Guay, Chun Sing Li: 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2. Merck Frosst Canada, Curtis C Panzer, David L Rose, February 18, 1997: US05604260 (149 worldwide citation)

The Compound of Formula I and pharmaceutically acceptable salts thereof in the treatment of cyclooxygenase-2 mediated diseases are disclosed.


3
W Cameron Black, Chun Sing Li, Daniel Guay, Petpiboon Prasit, Patrick Roy: Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase. Merck Frosst Canada, Curtis C Panzer, David L Rose, April 25, 1995: US05409944 (113 worldwide citation)

Disclosed are compounds of Formula I useful in the treatment of cyclooxygenase mediated diseases such as pain, fever and inflammation of a variety of conditions including rheumatic fever, symptoms associated with influenza or other viral infections, common cold, low back and neck pain, dysmenorrhea, ...


4
Michel Belley, Jacques Yves Gauthier, Erich Grimm, Yves LeBlanc, Chun Sing Li, Michel Therien, Cameron Black, Petpiboon Prasit, Cheuk Kun Lau, Patrick Roy: (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors. Merck Frosst Canada, Richard C Billups, David L Rose, February 1, 2000: US06020343 (25 worldwide citation)

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.


5

6

7

8
Michel Belley, Jacques Yves Gauthier, Erich Grimm, Yves LeBlanc, Chun Sing Li, Michel Therien, Cameron Black, Petpiboon Prasit, Cheuk Kun Lau, Patrick Roy: (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors. Merck Frosst Canada, Richard C Billups, David L Rose, November 9, 1999: US05981576 (6 worldwide citation)

The invention encompasses the novel compound of Formula A that is useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula A.


9
Daniel Guay, Chun Sing Li, Nathalie Ouimet: 5-Methanesulfonamido-3H-isobenzofuran-1-ones as inhibitors of cyclooxygenase-2. Merck Frosst Canada, Richard C Billups, Curtis C Panzer, David L Rose, October 19, 1999: US05968958 (5 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encomp ...


10
Chun Sing Li, Jacques Y Gauthier, Cheuk K Lau, Michel Therien: Pyridazinones as inhibitors of cyclooxygenase-2. Merck Frosst Canada, Richard C Billups, David L Rose, December 21, 1999: US06004960 (5 worldwide citation)

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encomp ...