1
Gary G Liversidge, Christopher P Phillips, Kenneth C Cundy: Method to reduce particle size growth during lyophilization. Sterling Winthrop, William J Davis, April 12, 1994: US05302401 (150 worldwide citation)

This invention discloses a composition comprised of nanoparticles having a surface modifier adsorbed on the surface thereof and a cryoprotectant associated therewith, which cryoprotectant is present in an amount sufficient to form a nanoparticle-cryoprotectant composition. A preferred surface modifi ...


2
Christopher P Phillips, Robert A Snow: Lyophilized polyethylene oxide modified protein and polypeptide complexes with cyclodextrin. Sterling Winthrop, Imre Balogh, William J Dupont Paul E Davis, June 25, 1996: US05529915 (104 worldwide citation)

Disclosed are lyophilized biologically active proteinaceous compositions containing low diol polyalkylene oxide, such as polyethylene glycol, covalently attached to a biologically active proteinaceous substance and combined with the cryoprotectant cyclodextrin.


3
Christopher P Phillips, Robert A Snow: Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life. Sterling Winthrop, Imre, Arthur Rosenstein, March 29, 1994: US05298410 (53 worldwide citation)

Disclosed are lyophilized biologically active proteinaceous compositions containing low diol polyalkylene oxide, such as polyethylene glycol, covalently attached to a biologically active proteinaceous substance and combined with the cryoprotectant cyclodextrin.


4
David J Burke, Shaun E Buckley, Sherwood Russ Lehrman, Barbara Horsey O Connor, James Callaway, Christopher P Phillips: Immunoglobulin formulation and method of preparation thereof. Elan Pharmaceuticals, Crowell & Moring, January 8, 2013: US08349321 (32 worldwide citation)

A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, polysorbate 80, a buffer which inhibits polysorbate oxidation is described along with methods of making the preparation. Also described are formulations with high antibody concentrations which m ...


5
Christopher P Phillips, Robert A Snow: Lyophilized polyethylene oxide modified protein and polypeptide complexes with cyclodextrin. Sterling Winthrop, Imre Balogh, February 14, 1995: US05389381 (13 worldwide citation)

Disclosed are lyophilized biologically active proteinaceous compositions containing low diol polyalkylene oxide, such as polyethylene glycol, covalently attached to a biologically active proteinaceous substance and combined with the cryoprotectant cyclodextrin.


6
Christopher P Phillips, Robert A Snow: Lyophilized polyethylene oxide modified catalase composition, polypeptide complexes with cyclodextrin and treatment of diseases with the catalase compositions. Sterling Winthrop, Arthur Rosenstein, Imre, August 2, 1994: US05334382 (12 worldwide citation)

Disclosed are lyophilized biologically active proteinaceous compositions containing low diol polyalkylene oxide, such as polyethylene glycol, covalently attached to a biologically active proteinaceous substance and combined with the cryoprotectant cyclodextrin.


7
David J Burke, Shaun E Buckley, Sherwood Russ Lehrman, Barbara Horsey O Connor, James Callaway, Christopher P Phillips: Method for treating multiple sclerosis and crohns disease. Biogen Idec MA, Yuko Soneoka, Arnold & Porter, August 26, 2014: US08815236

A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, polysorbate 80, a buffer which inhibits polysorbate oxidation is described along with methods of making the preparation. Also described are formulations with high antibody concentrations which m ...


8
David J Burke, Shaun E Buckley, Sherwood Russ Lehrman, Barbara Horsey O Connor, James Callaway, Christopher P Phillips: Immunoglobulin formulation and method of preparation thereof. Biogen Idec Ma, Yuko Soneoka, Arnold & Porter, December 2, 2014: US08900577

A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, polysorbate 80, a buffer which inhibits polysorbate oxidation is described along with methods of making the preparation. Also described are formulations with high antibody concentrations which m ...


9
David J Burke, Shaun E Buckley, Sherwood Russ Lehrman, Barbara Horsey O Connor, James Callaway, Christopher P Phillips: Immunoglobulin Formulation and Method of Preparation Thereof. Elan Pharmaceuticals, December 27, 2012: US20120328614-A1

A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, polysorbate 80, a buffer which inhibits polysorbate oxidation is described along with methods of making the preparation. Also described are formulations with high antibody concentrations which m ...