1
David T Curiel, Max L Birnstiel, Matthew Cotten, Ernst Wagner, Kurt Zatloukal, Christian Plank, Berndt Oberhauser, Walter G M Schmidt: Composition for introducing nucleic acid complexes into higher eucaryotic cells. Boehringer Ingelheim International, Genentech, Sterne Kessler Goldstein & Fox P L L C, August 20, 1996: US05547932 (198 worldwide citation)

A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic ag ...


2
David T Curiel, Max L Birnstiel, Matthew Cotten, Ernst Wagner, Kurt Zatloukal, Christian Plank, Berndt Oberhauser, Walter G M Schmidt: Composition for introducing nucleic acid complexes into higher eucaryotic cells. Boehringer Ingelheim International, Genetech, The University of North Carolina at Chapel Hill, Sterne Kessler Goldstein & Fox P L L C, February 8, 2000: US06022735 (21 worldwide citation)

A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic ag ...


3
David T Curiel, Max L Birnstiel, Matthew Cotten, Ernst Wagner, Kurt Zatloukal, Christian Plank, Berndt Oberhauser, Walter G M Schmidt: Composition for introducing nucleic acid complexes into higher eucaryotic cells. Boehringer Ingelheim International, Genentech, The University of North Carolina at Chapel Hill, Sterne Kessler Goldstein & Fox P L L C, August 14, 2001: US06274322 (20 worldwide citation)

A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic ag ...


4
David T Curiel, Max L Birnstiel, Matthew Cotten, Ernst Wagner, Kurt Zatloukal, Christian Plank, Berndt Oberhauser, Walter G M Schmidt: Composition for introducing nucleic acid complexes into higher eucaryotic cells. Boehringer Ingelheim International, Genentech, The University of North Carolina at Chapel Hill, Sterne Kessler Goldstein & Fox P L L C, June 20, 2000: US06077663 (18 worldwide citation)

A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic ag ...


5
David T Curiel, Max L Birnstiel, Matthew Cotten, Ernst Wagner, Kurt Zatloukal, Christian Plank, Berndt Oberhauser, Walter G M Schmidt: Composition comprising an endosomolytic agent for introducing nucleic acid complexes into higher eucaryotic cells. Boehringer Ingelheim Int l, Genentech, The University of North Carolina, Sterne Kessler Goldstein & Fox P L L C, November 9, 1999: US05981273 (17 worldwide citation)

A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic ag ...


6
Michael Heartlein, Braydon Charles Guild, Frank DeRosa, Carsten Rudolph, Christian Plank, Lianne Smith: CFTR mRNA compositions and related methods and uses. Shire Human Genetic Therapies, Ethris, Choate Hall & Stewart, Fangli Chen, November 10, 2015: US09181321 (2 worldwide citation)

Materials, formulations, production methods, and methods for delivery of CFTR mRNA for induction of CFTR expression, including in the mammalian lung are provided. The present invention is particularly useful for treating cystic fibrosis.


7
Michael Heartlein, Braydon Charles Guild, Frank DeRosa, Carsten Rudolph, Christian Plank, Lianne Smith: CFTR mRNA compositions and related methods and uses. RaNA Therapeutics, Ethris, Fangli Chen, Proskauer Rose, July 25, 2017: US09713626

Pharmaceutical compositions comprising an mRNA-loaded nanoparticle, wherein the mRNA is an in vitro transcribed mRNA and has a coding sequence at least 80% identical to SEQ ID NO: 3, and wherein the mRNA encodes a human cystic fibrosis transmembrane conductance regulator (CFTR) protein comprising th ...


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Christian Plank, Christian Bergemann: Method for transfecting cells using a magnetic field. Birch Stewart Kolasch & Birch, July 4, 2002: US20020086842-A1

Described is a method for transfecting a cell comprising bringing a complex comprising vector(s) and magnetic particle(s) in contact with a cell by applying a magnetic field and methods of treatment using said method. Furthermore, described is such a complex as well as methods for making it. Finally ...


10
Joseph Rosenecker, Carsten Rudolph, Christian Plank, Markus Elfinger: Transport of Nano-and Macromolecular Structures Into Cytoplasm and Nucleus of Cells. Ludwig Maximilians Universität, Technische Universität München, Connolly Bove Lodge & Hutz, December 11, 2008: US20080305038-A1

The present invention refers to novel conjugate molecules and their use or the transport of nano- and macromolecular structures into cells and/or the nucleus. More particularly, the present invention refers to conjugate molecules containing a carrier, preferably thiopyridyl moieties, and a cargo moi ...