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Seo Min Hyo, Kim Bong Oh, Choi In Ja, Shim Myung Seob, Lee Sa Won, Hyun Myung Han, Yu Jung Il, Chang Dong Hoon, Kim Jeong Kyung, Yoon Hye Jeong: Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery. Samyang Corporation, CHOI Kyu Pal, April 21, 2005: WO/2005/035606 (5 worldwide citation)

The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions c ...


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Seo Min Hyo, Kim Bong Oh, Choi In Ja, Shim Myung Seob: Biodegradable branched polylactide derivativescapable of forming polymeric micelles, and their preparation method and use. Samyang Corporation, Seo Min Hyo, Kim Bong Oh, Choi In Ja, Shim Myung Seob, CHOI Kyu Pal, June 16, 2005: WO/2005/054333 (3 worldwide citation)

The present invention relates to a biodegradable branched polylactic acid derivative of formula 1, and preparation method and use thereof: 1-(R-X)n wherein each of X, R, I and n is defined as in the detailed description.


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Choi In Ja, Seo Min Hyo, Kim Bong Oh, Shim Myung Seob: Composition for inhibiting adhesion. Samyang Corporation, Choi In Ja, Seo Min Hyo, Kim Bong Oh, Shim Myung Seob, YOU ME PATENT Seolim bldg 649 10 Yoksam dong Kangnam ku Seoul 135 080, August 9, 2007: WO/2007/089103 (2 worldwide citation)

There is provided in the present invention a composition for inhibiting adhesion comprising polymers that are dissolved in an aqueous solution and have temperature sensitivity showing a sol-gel phase transition dependant upon temperature, wherein the polymer solution in a sol state becomes a gel sta ...


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Seo Min Hyo, Choi In Ja: Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof. Samyang, July 31, 2002: EP1226212-A1 (1 worldwide citation)

A composition capable of forming a micelle in body fluids or in an aqueous medium and that can be injected into the body undiluted or as a diluted solution in an aqueous medium and method for preparation thereof are disclosed. The composition comprises an amphiphilic block copolymer having a hydroph ...


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Seo Min Hyo, Choi In Ja: Liquid composition of biodegradable block copolymer for drug delivery system and process for the preparation thereof. Samyang, October 2, 2002: EP1244471-A1 (1 worldwide citation)

The present invention relates to a liquid polymeric composition capable of forming a physiologically active substance-containing implant when it is injected into a living body and a method of preparation thereof. The composition comprises a water-soluble biocompatible liquid polyethylene glycol deri ...


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Choi In Ja, Seo Min Hyo: Biodegradable block copolymer of hydrophobic polymer and hydrophilic polymer and composition of drug delivery system. Samyang Corporation, February 5, 2001: KR1019990029269 (1 worldwide citation)

PURPOSE: A biodegradable block copolymer of hydrophobic polymer and hydrophilic polymer and a composition of drug delivery system are provided. The copolymer has a low melting point and can be easily dissolved in organic solvent and a drug can be enclosed by the copolymer under low temperature. CONS ...


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Seo Min Hyo, Choi In Ja, Kong Han Uk: Negatively charged amphiphilic block copolymer as drug carrier and complex thereof with positively charged drug. Samyang, March 24, 2004: EP1399501-A1

The present invention provides an anionic group-containing amphiphilic block copolymer that is biocompatible and biodegradable and, when used as a drug carrier for a cationic drug, provides several advantages such as increased blood concentration and improved stability of the drug.


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Seo Min Hyo, Choi In Ja: Biodegradable poly(alkylene oxide)-poly(p-dioxanone) block copolymer soluble in organic solvents, and drug delivery composition comprising same. Samyang, April 17, 2002: EP1196149-A1

The present invention relates to a biocompatible and biodegradable block copolymer of poly(alkylene oxide) and poly(p-dioxanone), which is soluble in organic solvents; and a drug delivery composition comprising the same.