1
Tann Chou Hong, Thiruvengadam Tiruvettipuram K, Chiu John Sze Hung, Colon Cesar: Process for preparing netilmicin.. Schering, April 22, 1987: EP0219093-A2 (1 worldwide citation)

A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2" positions, and optionally at the 4" position, converting the 1-amino substituents to a 1-N-imino substituent, converting the imino to an ethylamino, ...


2
Tann Chou Hong, Thiruvengadam Tiruvettipuram K, Chiu John Sze Hung, Colon Cesar, Green Michael D: Improved process for preparing isepamicin.. Schering, January 2, 1991: EP0405820-A2

An improved process for converting gentamicin B to isepamicin comprising forming 3,6 min -di-N-formylgentamicin B, acylating the 1-amino group with an N-protected (S)-isoserine compound and removing all the blocking groups under conditions which result in high yields of isepamicin. A novel formylati ...


3
Tann Chou Hong, Thiruvengadam Tiruvettipuram K, Chiu John Sze Hung, Colon Cesar: Process for preparing netilmicin.. Schering, October 28, 1987: EP0242385-A1

A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2" positions, and optionally at the 4" position, converting the 1-amino substituents to a 1-N-imino substituent, converting the imino to an ethylamino, ...


4
Tann Chou Hong, Thiruvengadam Tiruvettipuram K, Chiu John Sze Hung, Colon Cesar, Green Michael D: N-protected-(s)-isoserine compounds.. Schering, June 16, 1993: EP0547031-A1

Novel isoserine compounds such as N; O-diformyl-(S)-isoserine and N-formyl-(S)-isoserine are described and used in a process for converting gentamicin B to isepamicin. Active esters are formed by reaction of the isoserine compounds with N-hydroxybenzotriazole, N-hydroxysuccinimide, imidazole, N-hydr ...


5
Tann Chou Hong, Thiruvengadam Tiruvettipuram Kannappan, Chiu John Sze Hung, Colon Cesar: Procede pour la preparation de la netilmicine, Process for preparing netilmicin. Schering Corporation, OGILVY RENAULT SENCRLSRL, October 15, 1991: CA1290751

ABSTRACTA high yielding process ofr converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the stepof silylating the starting material at the 5, 2"positions, and optionally at the 4" positon, convertingthe 1-amino substituents to a 1-N-imino substituent,converting the imino to an ethylam ...


6
Tann Chou Hong, Thiruvengadam Tiruvettipuram Kannappan, Chiu John Sze Hung, Colon Cesar, Green Michael D: Improved process for preparing isepamicin. Schering Corporation, Tann Chou Hong, Thiruvengadam Tiruvettipuram Kannappan, Chiu John Sze Hung, Colon Cesar, Green Michael D, MAJKA Joseph T, December 27, 1990: WO/1990/015810

An improved process for converting gentamicin B to isepamicin comprising forming 3,6'-di-N-formylgentamicin B, acylating the 1-amino group with an N-protected (S)-isoserine compound and removing all the blocking groups under conditions which result in high yields of isepamicin. A novel formylating a ...


7
Tann Chou Hong, Thiruvengadam Tiruvettipuram Kannappan, Chiu John Sze Hung, Colon Cesar: Process for preparing netilmicin. Schering Corporation, KANSTAD Steinar V, April 23, 1987: WO/1987/002365

A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2'' positions, and optionally at the 4'' position, converting the 1-amino substituents to a 1-N-imino substituent, converting the imino to an ethylamin ...


8
Tann Chou Hong, Thiruvengadam Tiruvettipuram K, Chiu John Sze Hung, Colon Cesar, Green Michael D: Improved process for preparing isepamicin.. Schering, April 8, 1992: EP0478707-A1

An improved process for converting gentamicin B to isepamicin comprising forming 3,6 min -di-N-formylgentamicin B, acylating the 1-amino group with an N-protected (S)-isoserine compound and removing all the blocking groups under conditions which result in high yields of isepamicin. A novel formylati ...