1
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Stably tethered structures of defined compositions with multiple functions or binding specificities. IBC Pharmaceuticals, Richard A Nakashima, April 21, 2009: US07521056 (73 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization an ...


2
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Methods and compositions for generating bioactive assemblies of increased complexity and uses. IBC Pharmaceuticals, Richard A Nakashima, May 19, 2009: US07534866 (72 worldwide citation)

The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) methodology, which ta ...


3
Chien Hsing Chang, David M Goldenberg, Edmund A Rossi: Multivalent immunoglobulin-based bioactive assemblies. IBC Pharmaceuticals, Richard A Nakashima, May 5, 2009: US07527787 (71 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or more IgG antibody fragments and w ...


4
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses. IBC Pharmaceuticals, Richard A Nakashima, June 23, 2009: US07550143 (70 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached ...


5
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: PEGylation by the dock and lock (DNL) technique. IBC Pharmaceuticals, Richard A Nakashima, February 23, 2010: US07666400 (68 worldwide citation)

The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a therapeutic agent to a DDD sequence and attaching a PEG moiety to a ...


6
Chien Hsing Chang, Goldenberg David M, Mcbride William J, Rossi Edmund A: Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses. Ibc Pharmaceuticals, Chien Hsing Chang, Goldenberg David M, Mcbride William J, Rossi Edmund A, NAKASHIMA Richard A, October 12, 2006: WO/2006/107617 (64 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached ...


7
Chien Hsing Chang, Goldenberg David M, Mcbride William J, Rossi Edmund A: Improved stably tethered structures of defined compositions with multiple functions or binding specificities. Ibc Pharmaceuticals, Chien Hsing Chang, Goldenberg David M, Mcbride William J, Rossi Edmund A, NAKASHIMA Richard A, October 12, 2006: WO/2006/107786 (60 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization an ...


8
Chien Hsing Chang, David M Goldenberg: Dock-and-lock (DNL) vaccines for cancer therapy. IBC Pharmaceuticals, Richard A Nakashima, March 8, 2011: US07901680 (44 worldwide citation)

The present invention concerns methods and compositions for forming anti-cancer vaccine DNL complexes using dock-and-lock technology. In preferred embodiments, the anti-cancer vaccine DNL complex comprises an antibody moiety that binds to dendritic cells, such as an anti-CD74 antibody or antigen-bin ...


9
Chien Hsing Chang, David M Goldenberg, William J McBride, Edmund A Rossi: Stably tethered structures of defined compositions with multiple functions or binding specificities. IBC Pharmaceuticals, Richard A Nakashima, January 18, 2011: US07871622 (38 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization an ...


10
Chien Hsing Chang, David M Goldenberg, Edmund A Rossi: Multivalent immunoglobulin-based bioactive assemblies. IBC Pharmaceuticals, Richard A Nakashima, December 28, 2010: US07858070 (37 worldwide citation)

The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or more IgG antibody fragments and w ...