1
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, March 18, 2008: US07345178 (45 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


2
Jean Bemis, Jeremy S Disch, Michael Jirousek, Walter Joseph Lunsmann, Pui Yee Ng, Chi B Vu: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, November 9, 2010: US07829556 (38 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


3
Jean Bemis, Jeremy S Disch, Pui Yee Ng, Christopher Oalmann, Robert B Perni, Chi B Vu: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, February 22, 2011: US07893086 (18 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


4
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch, Thomas Salzmann, David Armistead: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, December 21, 2010: US07855289 (18 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


5
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, January 10, 2012: US08093401 (17 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


6
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch, Thomas Salzmann, David Armistead: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, January 3, 2012: US08088928 (17 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


7
Kristin Marie Lundy, Chi B Vu: Amide derivatives of 16-membered ring antibiotic macrolides. Pfizer, Peter C Richardson, Gregg C Benson, February 10, 1998: US05716939 (16 worldwide citation)

The present invention relates to amide derivatives of formula (I) or (II) of 19-carboxy-19-deformyl 16-membered ring macrolide antibiotics rosaramicin, repromicin, tylosin, 5-O-mycaminosyltylonolide, 4-deoxy-O-mycaminosyltylonolide, desmycosin lactenocin, O-demethyllactenocin, cirramycin A.sub.1, an ...


8
Joseph J Nunes, Jill Milne, Jean Bemis, Roger Xie, Chi B Vu, Pui Yee Ng, Jeremy S Disch: Sirtuin modulating compounds. Sirtris Pharmaceuticals, Ropes & Gray, October 25, 2011: US08044198 (13 worldwide citation)

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to agin ...


9
Jill C Milne, Michael R Jirousek, Jean E Bemis, Chi B Vu: Fatty acid niacin conjugates and their uses. Catabasis Pharmaceuticals, Cooley, November 6, 2012: US08304551 (12 worldwide citation)

The invention relates to fatty acid niacin conjugates; compositions comprising an effective amount of a fatty acid niacin conjugate; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a fatty acid niacin conjugate.


10
Chi B Vu, Jean E Bemis, Michael R Jirousek, Jill C Milne, Jesse J Smith: Fatty acid acylated salicylates and their uses. Catabasis Pharmaceuticals, Goodwin Procter, July 21, 2015: US09085527 (9 worldwide citation)

The invention relates to fatty acid acylated salicylate derivatives; compositions comprising an effective amount of a fatty acid acylated salicylate derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a fatty acid acylat ...