1
Chengbin Wu, Tariq Ghayur, Richard W Dixon, Jochen G Salfeld: Dual variable domain immunoglobulin and uses thereof. Abbott Laboratories, Tara Seshadri, Kenneth Zwicker, Yankwich & Associates P C, November 3, 2009: US07612181 (139 worldwide citation)

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.


2
Chengbin Wu, Tariq Ghayur, Richard W Dixon, Jochen G Salfeld: Dual variable domain immunoglobulin and uses thereof. Abbott Laboratories, Peter Dini, Yankwich & Associates P C, September 4, 2012: US08258268 (46 worldwide citation)

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.


3
Chengbin Wu, Richard W Dixon, Jonathan P Belk, Maria A Argiriadi, Hua Ying, Carolyn A Cuff, Terry L Melim, Shankar Kumar, Paul R Hinton, Yan Chen: Interleukin-13 binding proteins. Abbott Laboratories, Kenneth Zwicker, Stephen J Gaudet, Yankwich & Associates P C, March 29, 2011: US07915388 (35 worldwide citation)

The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention ca ...


4
Tariq Ghayur, Peter C Isakson, Lisa M Olson, Chengbin Wu, Margaret Hugunin, Rajesh V Kamath, Carolyn A Cuff, Hamish J Allen: Dual variable domain immunoglobulins and uses thereof. AbbVie, Finnegan Henderson Farabow Garrett & Dunner, May 19, 2015: US09035027 (14 worldwide citation)

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.


5
Chengbin Wu, Dominic J Ambrosi, Chung ming Hsieh, Tariq Ghayur: IL-I binding proteins. AbbVie, Peter W Dini, James H Velema Esq, Lathrop & Gage, March 4, 2014: US08664367 (6 worldwide citation)

Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.


6
Chengbin Wu, Dominic J Ambrosi, Chung ming Hsieh, Tariq Ghayur: Dual variable domain immunnoglobulins and uses thereof. ABBVIE, Peter W Dini, James H Velema Esq, Lathrop & Gage, October 7, 2014: US08853365 (6 worldwide citation)

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.


7
Chengbin Wu, Dominic J Ambrosi, Chung ming Hsieh, Tariq Ghayur: IL-1 binding proteins. ABBVIE, Peter W Dini, James H Velema Esq, Lathrop & Gage, September 23, 2014: US08841417 (5 worldwide citation)

Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.


8
Chengbin Wu, Chung ming Hsieh, Renee Miller, Dominic J Ambrosi: IL-1 binding proteins. AbbVie, Lathrop & Gage, James H Velema Esq, March 19, 2013: US08398966 (4 worldwide citation)

The present invention describes IL-1β binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1β. Binding proteins of the invention have high affinity for IL-1β and neutralize IL-1β activity. A binding protein of the invention can be a full-length antibody or an IL-1 ...


9
Chung ming Hsieh, Chengbin Wu: IL-1 binding proteins. AbbVie, Lathrop & Gage, James H Velema Esq, February 26, 2013: US08383778 (3 worldwide citation)

The present invention encompasses IL-1α binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Antibodies of the invention have high affinity for IL-1α and neutralize IL-1α activity. An antibody of the invention can be a full-leng ...


10
Chengbin Wu, Dominic J Ambrosi, Chung ming Hsieh, Tariq Ghayur: IL-1 binding proteins. AbbVie, Lathrop & Gage, James H Velema Esq, September 20, 2016: US09447184 (2 worldwide citation)

Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.