1
Eric A Swanson, David Huang, James G Fujimoto, Carmen A Puliafito, Charles P Lin, Joel S Schuman: Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample. Massachusetts Institute of Technology, Wolf Greenfield & Sacks, June 14, 1994: US05321501 (787 worldwide citation)

A method and apparatus for performing optical imaging on a sample wherein longitudinal scanning or positioning in the sample is provided by either varying relative optical path lengths for an optical path leading to the sample and to a reference reflector, or by varying an optical characteristic of ...


2
Eric A Swanson, David Huang, James G Fujimoto, Carmen A Puliafito, Charles P Lin, Joseph S Schuman: Method and apparatus for performing optical measurements. Massachusetts Institute of Technology, Wolf Greenfield & Sacks, October 17, 1995: US05459570 (529 worldwide citation)

A method and apparatus for performing various optical measurements is provided utilizing an optical coherence domain refrectometer (OCDR). A short coherence optical radiation source applies optical radiation through like optical paths to a sample and an optical reflector. The optical reflector is mo ...


3
Charles P Lin: Selective photocoagulation. The General Hospital Corporation, Fish & Richardson P C, October 3, 2006: US07115120 (72 worldwide citation)

Selective photocoagulation of particular cells, tissue or portion of tissue can be aided by monitoring microcavitation within the material exposed to electromagnetic radiation (12). The information gained by the detection of microcavitation events can be used to modulate the intensity of the radiati ...


4
Charles P Lin, Robert H Webb: Fiber-coupled multiplexed confocal microscope. The General Hospital Corporation, Thomas J Kowalski, Amy Leahy, Frommer Lawrence & Haug, June 8, 2004: US06747795 (21 worldwide citation)

A confocal microscope system that is inherently fiberoptic compatible is described which has line scanning aided image formation. An incoherent fiberoptic bundle maps a line illumination pattern into a dispersible group of separate sources, and then remaps this confocally selected remitted light to ...


5
Irene Georgakoudi, Charles P Lin: Methods of in vivo cytometry. The General Hospital, William C Geary III, Reza Mollaaghababa, Nutter McClennen & Fish, September 4, 2007: US07264794 (16 worldwide citation)

The present invention provides methods and systems for performing in-vivo flow cytometry to obtain desired information regarding one or more cell types of interest flowing through a subject's circulatory system. In one embodiment of the invention, a portion of the subject's circulating blood is illu ...


6
Charles P Lin, Clemens Alt: Optical devices and methods for selective and conventional photocoagulation of the retinal pigment epithelium. The General Hospital Corporation, Fish & Richardson P C, February 5, 2013: US08366704 (10 worldwide citation)

The present invention provides devices and methods for applying radiation to the retina of a patient. In one embodiment, an apparatus includes a radiation source for generating a radiation beam suitable for absorption by retinal pigment epithelial cells. One or more optical components are included t ...


7
Charles P Lin, Clemens Alt: Optical devices and methods for selective and conventional photocoagulation of the retinal pigment epithelium. The General Hospital Corporation, Fish & Richardson P C, May 29, 2012: US08187257 (10 worldwide citation)

The present invention provides devices and methods for applying radiation to the retina of a patient. In one embodiment, an apparatus includes a radiation source for generating a radiation beam suitable for absorption by retinal pigment epithelial cells. One or more optical components are included t ...


8
Charles P Lin: In vivo flow cytometry system and method. The General Hospital Corporation, Nutter McClennen & Fish, William C Geary III, Reza Mollaaghababa, February 17, 2009: US07491502 (9 worldwide citation)

The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in vivo so as to excite the fluorescent probes, and the rad ...


9
Charles P Lin, Robert H Webb: Fiber-coupled multiplexed confocal microscope. The General Hospital Corporation, Edwards Angell Palmer & Dodge, Peter C Lauro Esq, George N Chaelas Esq, November 6, 2007: US07292390 (6 worldwide citation)

A confocal microscope system that is inherently fiberoptic compatible is described which has line scanning aided image formation. An incoherent fiberoptic bundle maps a line illumination pattern into a dispersible group of separate sources, and then remaps this confocally selected remitted light to ...


10
Charles P Lin, Alicia L Carlson, Clemens Alt, David P Biss, Costas M Pitsillides, Chunqiang Li: In vivo flow cytometry based on cellular autofluorescence. The General Hospital Corporation, Nutter McClennen & Fish, November 5, 2013: US08574859 (5 worldwide citation)

The present invention generally provides methods and systems for performing in vivo flow cytometry by using blood vessels as flow chambers through which flowing cells can be monitored in a live subject in vivo without the need for withdrawing a blood sample. In some embodiments, one or more blood ve ...