31
Charles F Milo, Matthew R Selmon, Richard E Hill, Fred H Co, Ronald G French: Methods and apparatus for crossing total occlusions in blood vessels. Wilson Sonsini Goodrich & Rosati, August 9, 2001: US20010012924-A1 (1 worldwide citation)

Total occlusions are crossed by passing a guidewire or other penetrating wire from a point proximal to the occlusion into a subintimal space between the intimal layer and adventitial layer of the blood vessel wall. The wire is advanced to a point distal to the occlusion and thereafter deflected back ...


32
Olexander Hnojewyj, Charles F Milo, Gregory M Cruise: Biocompatible material composition adaptable to diverse therapeutic indications. Neomend, Pepper Hamilton, April 2, 2013: US08409605

A kit for forming a biocompatible material provides a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three. Upon mixing. the protein solution and the polymer solution cross-link to form a non-liquid, three-dimensional network ...


33
Matthew R Selmon, Charles F Milo, Robert L Wynne, Suresh S Pai, Kent D Dell, Charles Gresl, Gerald Hansen, E Richard Hill: Blunt micro-dissection catheter. Shemwell Gregory & Courtney, April 22, 2004: US20040077999-A1

An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed posi ...


34
Derek J Harper, Charles F Milo: Methods and implantable devices and systems for long term delivery of a pharmaceutical agent. MicroSolutions, Young Law Firm, A Professional Corporation, June 10, 2004: US20040111080-A1

Implantable devices and osmotic pump and catheter systems for delivering a pharmaceutical agent to a patient at selectable rates include an impermeable pump housing and a moveable partition disposed within the housing, the partition dividing the housing into an osmotic driving compartment having an ...


35
Bruce Addis, Charles F Milo, Olexander Hnojewyj: Systems, methods, and compositions for achieving closure of vascular puncture sites. NeoMend, Ryan Kromholz & Manion Sc, May 29, 2003: US20030100921-A1

Systems and methods convey a closure material into a catheter, e.g., to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components, which, upon mixing, undergo a reaction to form solid closure material composition. The first component may be a lyo ...


36
Derek J Harper, Charles F Milo: Implantable devices with invasive and non-invasive reversible infusion rate adjustability. MicroSolutions, Young Law Firm, A Professional Corporation, January 22, 2004: US20040015154-A1

An implantable pump for delivering a pharmaceutical agent includes a pump engine, a piston, a pharmaceutical agent compartment and a rate adjustment assembly. The pharmaceutical agent compartment is configured to enclose a volume of pharmaceutical agent and the piston. When the piston is acted upon ...


37
Charles F Milo, Olexander Hnojewyj, Timothy J McCoy, Bruce S Addis: Systems, methods, and compositions for achieving closure of vascular puncture sites. NeoMend, Ryan Kromholz & Manion Sc, November 29, 2001: US20010047187-A1

Systems and methods convey a closure material into a catheter to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components which, upon mixing, undergo a reaction to form a solid closure material composition. The systems and methods assure ease of ...


38
Derek J Harper, Charles F Milo: Osmotic pump drug delivery systems and methods. MicroSolutions, Young Law Firm, A Professional Corporation, February 13, 2003: US20030032947-A1

Implantable osmotic pump devices and systems include multiple osmotic pumps and/or semipermeable membranes to extend the useful life cycle and functionality of the drug delivery system. Use of an implantable system including multiple implantable osmotic pumps allows different drugs to be administere ...


39
Derek J Harper, Charles F Milo: Implantable osmotic pump. Young Law Firm, A Professional Corporation, December 5, 2002: US20020183722-A1

An implantable osmotic pump for delivering a pharmaceutical agent to a patient includes an osmotic engine, a substantially toroidal compartment disposed at least partially around the osmotic engine and a piston disposed within the compartment. The osmotic engine is configured to cause the piston to ...


40
Olexander Hnojewyj, Charles F Milo, Gregory M Cruise: Biocompatible material composition adaptable to diverse therapeutic indications. NeoMend, Ryan Kromholz & Manion Sc, July 24, 2008: US20080175817-A1

A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.