21
Derek J Harper, Charles F Milo: Implantable osmotic pump. MicroSolutions, Young Law Firm P C, October 14, 2003: US06632217 (61 worldwide citation)

An implantable osmotic pump for delivering a pharmaceutical agent to a patient includes an osmotic engine, a substantially toroidal compartment disposed at least partially around the osmotic engine and a piston disposed within the compartment. The osmotic engine is configured to cause the piston to ...


22
Derek J Harper, Charles F Milo: Methods and implantable devices and systems for long term delivery of a pharmaceutical agent. MicroSolutions, Young Law Firm P C, August 20, 2002: US06436091 (44 worldwide citation)

Implantable devices and osmotic pump and catheter systems for delivering a pharmaceutical agent to a patient at selectable rates include an impermeable pump housing and a moveable partition disposed within the housing, the partition dividing the housing into an osmotic driving compartment having an ...


23
Charles F Milo, Olexander Hnojewyj, Timothy J McCoy, Bruce S Addis: Systems, methods, and compositions for achieving closure of vascular puncture sites. NeoMend, Ryan Kromholz & Manion S C, September 27, 2005: US06949114 (35 worldwide citation)

Systems and methods convey a closure material into a catheter to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components which, upon mixing, undergo a reaction to form a solid closure material composition. The systems and methods assure ease of ...


24
Olexander Hnojewyj, Charles F Milo, Gregory M Cruise: Biocompatible material composition adaptable to diverse therapeutic indications. NeoMend, Ryan Kromholz & Manion S C, May 31, 2005: US06899889 (27 worldwide citation)

A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.


25
Olexander Hnojewyj, Charles F Milo, Gregory M Cruise: Biocompatible material composition adaptable to diverse therapeutic indications. Neomend, Ryan Kromholz and Manion S C, July 24, 2007: US07247314 (15 worldwide citation)

A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.


26
Derek J Harper, Charles F Milo: Osmotic pump delivery system with flexible drug compartment. Microsolutions, Young Law Firm P C, October 15, 2002: US06464688 (7 worldwide citation)

An implantable osmotic pump system includes a rigid pump housing defining an opening adapted to receive a catheter; one or more membrane assemblies fitted to the pump housing; an osmotic engine within the rigid pump housing and a flexible pharmaceutical agent compartment disposed within the pump hou ...


27
Derek J Harper, Charles F Milo: Osmotic pump delivery system with pre-hydrated membrane(s) and/or primable catheter. Microsolutions, Young Law Firm P C, September 9, 2003: US06616652 (2 worldwide citation)

An implantable osmotic pump system includes a pre-hydrated semipermeable membrane to reduce the time interval between implantation of the system into the patient and full operation of the pump system. The semipermeable membrane is maintained in a hydrated state prior to implantation by fluid contact ...


28
Charles F Milo, Matthew R Selmon, Richard E Hill, Fred H Co, Ronald G French: Re-entry catheter. Lumend, Shemwell Gregory & Courtney, June 26, 2003: US20030120195-A1 (2 worldwide citation)

Total occlusions are crossed by passing a guidewire or other penetrating wire from a point proximal to the occlusion into a subintimal space between the intimal layer and adventitial layer of the blood vessel wall. The wire is advanced to a point distal to the occlusion and thereafter deflected back ...


29
Matthew R Selmon, Charles F Milo, Robert L Wynne, Suresh S Pai, Kent D Dell, Charles Gresl, Gerald Hansen, E Richard Hill: Methods and apparatus for treating vascular occlusions. Wilson Sonsini Goodrich & Rosati, August 30, 2001: US20010018596-A1 (2 worldwide citation)

An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed posi ...


30
Matthew R Selmon, Charles F Milo, Fred Co, Mark Campello, Ronald French, Amiel Aguilar: Methods and apparatus for crossing vascular occlusions. Wilson Sonsini Goodrich & Rosati, March 15, 2001: US20010000041-A1 (2 worldwide citation)

Methods and apparatus for crossing totally to substantially occluded blood vessels by passing a redirectable wire such as a guidewire from a relatively proximal point past the occlusion within a subintimal space formed between the intimal layer and the adventitial layer of a blood vessel wall. The w ...