1
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Jones & Askew, July 18, 2000: US06090925 (165 worldwide citation)

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromol ...


2
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard, Frank J Riske: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Jones & Askew, November 9, 1999: US05981719 (145 worldwide citation)

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromol ...


3
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard, Frank J Riske: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Wolf Greenfield & Sacks P C, July 31, 2001: US06268053 (114 worldwide citation)

Methods relating to the field of biochemistry and more specifically relating to microparticles for use in diagnostics, therapeutics, and research are provided.


4
Terrence L Scott, Larry R Brown, Frank J Riske, Charles D Blizzard, Julia Rashba Step: Sustained release microspheres. Epic Therapeutics, Wolf Greenfield & Sacks P C, October 1, 2002: US06458387 (90 worldwide citation)

Methods for forming sustained release microspheres and the products produced thereby are provided. The microspheres have a smooth surface that includes a plurality of channel openings that are less than 1000 angstroms in diameter.


5
James E Woiszwillo, Larry R Brown, Terrence L Scott, Jie Di, Judith Sudhalter, Charles D Blizzard: Macromolecular microparticles and methods of production and use. Epic Therapeutics, Jones Askew, December 15, 1998: US05849884 (7 worldwide citation)

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromol ...


6
Charles D Blizzard, Michael M Lipp, Kevin L Ward, Rachel Ryznal, Daniel Leblanc, Mark Tracy, Rebecca Martin: Pulmonary pharmaceutical formulations. Civitas Therapeutics, Darlene A Vanstone Esq, Carolyn S Elmore Esq, Elmore Patent Law Group P C, December 24, 2013: US08614255 (3 worldwide citation)

The present invention provides improved pharmaceutical formulations for pulmonary delivery having improved chemical and physical stability of the therapeutic, prophylactic or diagnostic agent as compared to formulations known in the art. The improved pharmaceutical formulations of the invention for ...


7
Peter Jarrett, Michael Bassett, Charles D Blizzard, Amarpreet S Sawhney: Drug delivery through hydrogel plugs. Incept, Dardi & Herbert PLLC, Curtis B Herbert, October 22, 2013: US08563027

An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with ...


8
Blair Jackson, Lloyd Johnston, Charles D Blizzard, Jeffrey Mintzes: hGH (human growth hormone) formulations for pulmonary administration. Advanced Inhalation Research, Elmorc Craig PC, January 15, 2004: US20040009231-A1

This invention relates to the administration of proteins by absorption from the lungs. In particular, it is concerned with providing therapeutic doses of human growth hormone to the bloodstream without irritating or otherwise damaging lung tissue. This invention also relates to the methods of delive ...


9
Terrence L Scott, Larry R Brown, Frank J Riske, Charles D Blizzard, Julia Rashba Step: Sustained release microspheres. John R Van Amsterdam PhD, Wolf Greenfield & Sacks PC, March 27, 2003: US20030059474-A1

Methods for forming sustained release microspheres and the products produced thereby are provided. The microspheres have a smooth surface that includes a plurality of channel openings that are less than 1000 angstroms in diameter.


10
Blair C Jackson, Lloyd P Johnston, Ernest E Penachio, Charles D Blizzard, Marie Chung, Jean Sung: Method and apparatus for producing dry particles. Covington & Burling, December 4, 2003: US20030222364-A1

Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneously combined. The present invention ...